National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterSeptember 2015

NTP Interagency Center for the Evaluation of Alternative Toxicological Methods

By Catherine Sprankle

Scientists Collaborate to Compile Reference Chemical List

NTP wants to develop a list of reference chemicals for use in the development, validation, and implementation of alternative methods for developmental toxicology testing. The goal is a list that is recognized internationally and can be used to evaluate chemicals in a variety of models including zebrafish and in vitro cell-based assays. To gather input on chemicals for the list, scientists from NICEATM and the Toxicology Branch, Division of NTP, NIEHS, are collaborating with experts from government, industry, and academia on recommendations for both known positive and negative developmental toxicants. Plans are underway to present the chemical reference list at the December meeting of the Validation Management Group–Non-Animal, an expert group within the Organisation for Economic Co-operation and Development that evaluates non-animal testing approaches for endocrine disruptors.

Presentations at ASCCT Annual Meeting

NICEATM scientists will present three posters and one oral presentation at the Annual Meeting of the American Society of Cellular and Computational Toxicology on October 1–2, 2015. This meeting is being held at the Environmental Protection Agency in Research Triangle Park, NC. The NICEATM presentations will highlight ongoing projects including (1) approaches for predicting in vivo effects from in vitro data, (2) reference chemicals for evaluating androgen receptor activity, (3) QSAR modeling for predicting androgen receptor pathway activity, and (4) computational approaches for predicting human skin sensitization hazards.

NICEATM Director Warren Casey, Ph.D., will give the plenary presentation “Moving Beyond One Test: Leveraging the Whole Toolbox for Integrated Decision Strategies,” and ICCVAM representative Joanna Matheson, Ph.D., of the Consumer Product Safety Commission, will present a case study on development of a non-animal integrated approach for identifying skin sensitizers.

Information about the ASCCT Annual Meeting is available at http://www.ascctox.org/meetings.cfm.

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