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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterOctober 2016


By Catherine Sprankle

NICEATM Director participates in Congressional briefing

NICEATM Director Warren Casey was a panelist for the September 13, 2016, Congressional briefing “Alternatives to Animal Testing: Emerging Uses and Policy Implications.” Casey and other panelists discussed how to use non-animal and alternative toxicology and safety testing methods to better protect consumers and public health while using fewer animals. Topics included how to spark research that advances the development and application of alternatives, as well as what policy discussions are required to ensure regulatory frameworks can adapt while realizing the fastest possible innovation. The briefing was organized by the American Chemical Society and the Johns Hopkins Bloomberg School for Public Health, and sponsored by the offices of Representatives Earl Blumenauer (D-OR) and Ken Calvert (R-CA).

NICEATM convenes expert meeting on inhalation toxicity

NICEATM and the PETA International Science Consortium organized an expert meeting on “Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-regulatory Data Requirements.” Participants in the meeting, held September 22-23, 2016, in Bethesda, MD, identified steps needed to reduce and replace animal use for required inhalation toxicity testing. They include establishing a database of existing toxicity data, preparing a state-of-the-science review on inhalation toxicity mechanisms, developing a decision tree to inform testing needs, and designing a proof-of-concept study for a non-animal testing approach.

This meeting followed a series of webinars presented by NICEATM and PISC on the same theme; information about the webinars is available at

Advisory committee discusses roadmap for replacing six acute toxicity tests

The Scientific Advisory Committee for Alternative Toxicological Methods met at the National Institute of Environmental Health Sciences on September 27, 2016. SACATM advises NICEATM and the Interagency Coordinating Committee on the Validation of Alternative Methods on NICEATM and ICCVAM activities. ICCVAM agencies outlined a roadmap for the replacement of animals for the six most commonly used acute toxicity tests. SACATM input was requested on the proposed effort to develop a strategy for the implementation of human-based predictive approaches for complex toxicological endpoints resulting from repeat dose studies, such as developmental toxicity and carcinogenicity. Materials from the meeting are available at

NICEATM presents at ASCCT Annual Meeting

NICEATM staff played key roles in the September 29-30 Annual Meeting of the American Society for Cellular and Computational Toxicology at the U.S. Environmental Protection Agency in Research Triangle Park, NC. Deputy NICEATM Director Nicole Kleinstreuer and ILS Computational Toxicologist Xiaoqing Chang gave platform presentations on NICEATM projects and ILS Senior Toxicologist Judy Strickland and Staff Toxicologist Agnes Karmaus presented a poster. Director Casey described a strategy for implementing human-based predictive approaches for toxicity testing. ASCCT President David Allen, ILS, welcomed attendees and led the ASCCT business meeting. Abstracts of NICEATM presentations and copies of posters presented at ASCCT are available at

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The Update Newsletter is produced by NTP Office of Liaison, Policy, and Review. The text is not copyrighted and can be reprinted without permission. If you use parts of the Update Newsletter in your publication, we ask that you provide us with a copy for our records. We welcome your comments and suggestions.

Director of Office of Liaison, Policy, and Review and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley