NICEATM Director participates in Congressional briefing
NICEATM Director Warren Casey was a panelist for the September 13, 2016, Congressional briefing “Alternatives to Animal Testing: Emerging Uses and Policy Implications.” Casey and other panelists discussed how to use non-animal and alternative toxicology and safety testing methods to better protect consumers and public health while using fewer animals. Topics included how to spark research that advances the development and application of alternatives, as well as what policy discussions are required to ensure regulatory frameworks can adapt while realizing the fastest possible innovation. The briefing was organized by the American Chemical Society and the Johns Hopkins Bloomberg School for Public Health, and sponsored by the offices of Representatives Earl Blumenauer (D-OR) and Ken Calvert (R-CA).
NICEATM convenes expert meeting on inhalation toxicity
NICEATM and the PETA International Science Consortium organized an expert meeting on “Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-regulatory Data Requirements.” Participants in the meeting, held September 22-23, 2016, in Bethesda, MD, identified steps needed to reduce and replace animal use for required inhalation toxicity testing. They include establishing a database of existing toxicity data, preparing a state-of-the-science review on inhalation toxicity mechanisms, developing a decision tree to inform testing needs, and designing a proof-of-concept study for a non-animal testing approach.
This meeting followed a series of webinars presented by NICEATM and PISC on the same theme; information about the webinars is available at http://ntp.niehs.nih.gov/go/inhalation-2016.
Advisory committee discusses roadmap for replacing six acute toxicity tests
The Scientific Advisory Committee for Alternative Toxicological Methods met at the National Institute of Environmental Health Sciences on September 27, 2016. SACATM advises NICEATM and the Interagency Coordinating Committee on the Validation of Alternative Methods on NICEATM and ICCVAM activities. ICCVAM agencies outlined a roadmap for the replacement of animals for the six most commonly used acute toxicity tests. SACATM input was requested on the proposed effort to develop a strategy for the implementation of human-based predictive approaches for complex toxicological endpoints resulting from repeat dose studies, such as developmental toxicity and carcinogenicity. Materials from the meeting are available at http://ntp.niehs.nih.gov/go/8202.