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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterDecember 2016

NTP Interagency Center for the Evaluation of Alternative Toxicological Methods

By Catherine Sprankle

NICEATM requests data on zebrafish embryo chemical screening

In a November 3 Federal Register notice (81 FR 76620), NICEATM requested available information on zebrafish embryo screening tests and protocol design, including pharmacokinetics measurements. NICEATM and collaborators will use this information to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential for chemicals to induce developmental effects in offspring.

Respondents to this data request should provide information on any activities relevant to the development or validation of zebrafish embryo screening assays. NICEATM specifically requests information on efforts to optimize zebrafish embryo screening tests and protocol design including comparisons of (1) zebrafish strains, (2) embryos with and without an intact chorion, and (3) static and static renewal exposures. NICEATM is also interested in developing a better understanding of pharmacokinetics in the zebrafish embryo model and requests available data on chemical uptake.

More information on this data request, including guidelines for data submission, is available at The deadline for receipt of the requested information is December 30, 2016.

Resources from the National Library of Medicine: ToxTutor and ALTBIB

NLM is a member of the Interagency Coordinating Committee on the Validation of Alternative Methods, which NICEATM supports. Two NLM resources, ToxTutor and ALTBIB, are of particular relevance to alternative methods development.

NLM recently updated ToxTutor, a self-paced Web tutorial for users of NLM chemical and toxicology databases that covers the key principles of toxicology. The ToxTutor update incorporates recent advances in the science of toxicology, provides more information on alternatives to animal testing, and features responsive design to support use on mobile devices. ToxTutor is available at

A December 8 NLM webinar will introduce users to the NLM database ALTBIB: Resources for Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing. The webinar will describe the history, purpose, and scope of ALTBIB; identify key people who work on ALTBIB; and demonstrate the features of the resource. Participants will gain hands-on experience with practice exercises and learn how ALTBIB can help with literature searches to identify alternatives to animal use. The webinar is free and open to residents of the United States. More information and a link to registration are available at

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The Update Newsletter is produced by NTP Office of Liaison, Policy, and Review. The text is not copyrighted and can be reprinted without permission. If you use parts of the Update Newsletter in your publication, we ask that you provide us with a copy for our records. We welcome your comments and suggestions.

Director of Office of Liaison, Policy, and Review and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley