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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterAugust 2016

Concern over perfluorinated chemicals increasing

By Ernie Hood
Reprinted from Environmental Factor

From three small towns in New York state, to research laboratories around the world and the halls of Congress, perfluorinated chemicals are becoming an increasing concern. Commercial production of perfluorooctanoic acid (PFOA) and perfluorooctane sulfate (PFOS) has been phased out in the United States, yet the chemicals may still pose a threat to the environment and human health (see sidebar).

In July, a National Toxicology Program (NTP) panel of experts peer reviewed a draft report on certain health effects, and NTP scientist Sue Fenton, Ph.D., attended a community meeting in New York, called by members of Congress who represent the towns.

Literature review leads to NTP draft monograph

With a growing body of literature suggesting immune system toxicity, the NTP Office of Health Assessment and Translation was asked in 2014 to evaluate the evidence for an association between exposure to PFOA and PFOS and immune-related health effects, and to determine the immune hazard presented by the chemicals. NTP completed an extensive evaluation of the scientific literature, and on July 19, representatives presented the draft report to a panel of experts for scientific peer review.

“There’s a relatively robust body of evidence [reporting] immune effects for both PFOA and PFOS in experimental animal models,” explained project leader Andrew Rooney, Ph.D. “And then there’s the emergence of a recent body of evidence reporting similar effects on the antibody response in humans.”

“And while PFOA and PFOS share some of the same health effects, there are also some differences,” he added.

Reviewers agree chemicals are presumed to be an immune hazard

The peer review panel voted unanimously to accept the conclusions that both PFOA and PFOS are presumed to be an immune hazard to humans. Presumed hazards are considered to be one step below a known hazard, on the five-step scale NTP uses for hazard identification, from not identified to known to be a hazard.

Both conclusions were based on evidence that these compounds suppress the body’s production of antibodies. Mice exposed to higher levels of PFOA or PFOS produced fewer antibodies when challenged with antigen. Similarly, humans with high levels of either chemical had lower antibody levels to common childhood vaccines. 

Additionally, the PFOS conclusion was supported by evidence of suppressed disease response and suppressed natural killer cell activity. Both are hallmarks of adverse immune effects.

Next, NTP will incorporate comments by the peer reviewers into the final monograph, which will be made publicly available.

PFOA on congressional radar

PFOA contamination in the drinking water of three communities near former manufacturing sites in New York led to action by Senators Charles Schumer, D-N.Y., and Kirsten Gillibrand, D-N.Y., and Representative Chris Gibson, R-N.Y. The three leaders sent a letter June 24 to the directors of the Centers for Disease Control and Prevention (CDC) and National Institutes of Health (NIH), asking the agencies to help educate and assist the people of the Village of Hoosick Falls and the Towns of Hoosick and Petersburgh.

“In the last two weeks, hundreds of residents in the Village of Hoosick Falls have received test results showing severely elevated levels of PFOA in their blood samples,” the officials noted in their letter.

Community meetings are being held in the area (see text box), and NIEHS is providing info and resources on PFOA and PFOS to congressional staff and communities. Linda Birnbaum, Ph.D., director of NIEHS and NTP, said that the institute continues to fund research by grantees and in-house researchers. “In Fiscal Year 2015, NIEHS obligated approximately $7.3 million for PFOA-related research,” she said.

(Ernie Hood is a contract writer for the NIEHS Office of Communications and Public Liaison.)

Hoosick Falls community meeting

Fenton, leader of the NTP Reproductive Endocrinology Group, represented NIH at a July 8 community meeting in Hoosick Falls, New York to discuss public health considerations and research associated with PFOA exposures. Fenton appeared at the request of Senator Gillibrand, who lives in Rensselaer County, where Hoosick Falls is located. CDC was represented by the director of its Agency for Toxic Substances and Disease Registry, Patrick Breysse, Ph.D.

“We were happy to participate,” said Fenton. “I’ve been researching this compound [PFOA] for at least twelve years, so I have quite a bit of experience with it, both with the health effects and mechanisms involved with this chemical.”

She said her role at the meeting was two-pronged. “I can answer questions on what I know has been reported in the literature, and I can help direct people to reports that are already out,” she said. “I also think we need to have a good listening ear, because there may be questions that we don’t have answers to.”

According to Fenton, area residents have been advised against drinking unfiltered local water. Most of them are using filters or drinking bottled water and have had their blood PFOA levels checked. At the meeting, those who had received their results were very vocal about their health concerns. “The woman who was sitting next to me had very elevated levels in her blood, as did her two children,” she said.

The remaining blood test results should be in hand soon, at which time another community forum will take place to provide further answers to questions about the health effects of PFOA exposure. “That is what the people of Hoosick Falls are most worried about — the health of their children,” said Fenton.

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The Update Newsletter is produced by NTP Office of Policy, Review, and Outreach. The text is not copyrighted and can be reprinted without permission. If you use parts of the Update Newsletter in your publication, we ask that you provide us with a copy for our records. We welcome your comments and suggestions.

Director of Office of Policy, Review, and Outreach and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley