National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterAugust 2016

The Society of Toxicology and NIEHS — 50 Years of Collaboration

By Kelly Lenox
Reprinted from Environmental Factor

The Society of Toxicology (SOT) celebrated the NIEHS 50th anniversary with a July 13 symposium at NIEHS. Speakers reflected on decades of collaboration and looked forward to working together to create a safer and healthier world by increasing the impact of the science of toxicology.

The symposium was followed by an SOT-sponsored reception at which scientists from NIEHS and area universities caught up with society members who were in town for the event.

Leaders look back

Leaders from the two organizations kicked off the afternoon presentations. Linda Birnbaum, Ph.D., director of NIEHS and the National Toxicology Program (NTP), was introduced by NTP toxicologist Cynthia Rider, Ph.D., chair of the event organizing committee. “[Dr. Birnbaum] is an incredible role model for women in science,” Rider said, noting that Birnbaum was the first female director of NIEHS and NTP, served as SOT Council president in 2004, and has been a member of SOT since 1982.

Birnbaum touched on highlights from the 50 years of NIEHS involvement in toxicology. She discussed toxicology research supported through the NIEHS grants and in-house research divisions, in addition to the milestones below.

  • 1978 — NTP was established in the Department of Health, Education, and Welfare, as it was then named.
  • 2004 — NTP issued a roadmap describing its vision for the 21st century, which led to the interagency effort known as Tox21 in 2008.
  • 2016 — The Fourteenth Report on Carcinogens will be released this year.

“I’m very proud that we’ve had a number of NIEHSers serve on [SOT] council,” she said, noting that Paul Foster, Ph.D., head of the NTP Toxicology Branch, recently began serving a three-year term.

SOT President John Morris, Ph.D., from the University of Connecticut, praised NIEHS training grants. “They are the lifeblood of the future of our field,” he said. According to Christie Drew, Ph.D., of the NIEHS Program Analysis Branch, nearly one in five current and past councilors and directors of SOT have associations with NIEHS training grant programs.

Morris also pointed to the 2016 SOT annual meeting for another measure of the significance of NIEHS contributions. “Nine of the 50-some sessions were chaired by NIEHS people,” he said. “That is an essential service to the society and to the profession.”

Scientists reflect on the field of toxicology

David Eaton, Ph.D., dean and vice provost of the University of Washington Graduate School of Public Health, talked about his early efforts to develop a toxicology curriculum for elementary and high school students.

He commended the focus on community outreach and education in NIEHS-funded environmental health core centers and Superfund Research Program centers, as well as resources from the Partnerships for Environmental Public Health program, coordinated by NIEHS program administrator Liam O’Fallon.

Eaton thanked NIEHS for the visionary leadership that all of its directors have shown. “Including focusing on prevention — a word that’s hard to find in a lot of NIH [National Institutes of Health] mission statements,” he said.

“What a great celebratory day,” said the next speaker, longtime NIEHS grantee Cheryl Walker, Ph.D., who will start a new position at Baylor College of Medicine this year. She described fundamental changes in the NIH system for reviewing toxicology research grant applications, which have proved beneficial.

Walker, a key player in that effort, thanked Birnbaum; John Bucher, Ph.D., associate director of NTP; Pat Mastin, Ph.D., deputy director of the NIEHS Division of Extramural Research and Training (DERT); and others for their guidance and perseverance in the process.

Looking to the future

Kristen Ryan, Ph.D., NTP toxicologist and a key organizer of the event, introduced the final speaker. Phoebe Stapleton, Ph.D., who is transitioning to a tenure-track position at Rutgers University, provided an important look forward, from her perspective as an early career researcher.

Stapleton took an unusual route into toxicologic research. Her background in exercise physiology led to an interest in how nanomaterials affect the inner linings of blood vessels and capillaries.

From her first trip to an SOT annual meeting, she said, the group has been crucial to her professional development. “There was a great deal of mentoring and networking,” Stapleton explained. SOT and NIEHS have both helped her identify potential collaborators. “Especially as we talk about resources dwindling, teaming up is going to be one of our best answers,” she said.

Afterward, Foster discussed the 50 years of interactions between society members and the institute. “Some were postdocs here, some may be grantees, and others are involved in NTP advisory boards,” he said. “We are colleagues.”


Cynthia Rider Rider thanked SOT for providing planning support for the event, particularly Clarissa Russell and April Brewer. (Photo courtesy of Steve McCaw)
Kembra Howdeshell. Ph.D., Barbara Abbot, Ph.D., and James Bonner, Ph.D., Kembra Howdeshell. Ph.D., center, from NTP, sat between Barbara Abbot, Ph.D., left, from the U.S. Environmental Protection Agency, and James Bonner, Ph.D., from North Carolina State University. (Photo courtesy of Steve McCaw)
Danielle Carlin Danielle Carlin, Ph.D., from DERT, is president of the North Carolina Society of Toxicology, one of the SOT regional chapters. (Photo courtesy of Steve McCaw)
Abramowitz Heindel Birnbaum’s observation that toxicology is a cross-cutting topic at NIEHS was reflected in the audience. Above, from left, Jerry Heindel, Ph.D., from DERT; Joel Abramowitz, Ph.D., from the Division of Intramural Research; and Foster, behind them, from NTP, listen as Duke University’s Joel Meyer, Ph.D., standing, asked the panel a question. (Photo courtesy of Steve McCaw)
Mike DeVito Michael DeVito, Ph.D., head of the NTP Laboratory, asked the panel what type of career focus would characterize successful toxicologists 10 years from now. (Photo courtesy of Steve McCaw)
Ofelia Olivero SOT council member Ofelia Olivero, Ph.D., from the National Cancer Institute, offered thoughts on training the next generation of toxicologists. (Photo courtesy of Steve McCaw)

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