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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterSeptember 2016


By Catherine Sprankle

ICCVAM publishes 2014-2015 Biennial Progress Report

The Interagency Coordinating Committee on the Validation of Alternative Methods 2014-2015 Biennial Progress Report is now available on the NTP website at This report describes the activities of ICCVAM and its member agencies from January 2014 through December 2015.

Key ICCVAM, ICCVAM agency, and NTP Interagency Center for the Evaluation of Alternative Toxicological Methods accomplishments summarized in the report include:

  • A computational approach developed by ICCVAM that integrates several types of data to predict human skin sensitization hazard without using animals;
  • A U.S. Environmental Protection Agency plan to adopt high throughput assays and computational models for detecting and measuring estrogen receptor bioactivity as an alternative for three Tier 1 tests, including the uterotrophic assay, currently used in the Endocrine Disruptor Screening Program to assess estrogen receptor activity;
  • Establishment of the ICCVAM Communities of Practice webinar series;
  • A NICEATM evaluation of acute oral and dermal toxicity data to determine if oral toxicity tests are sufficient to assign EPA dermal hazard classifications, eliminating the need for separate acute dermal toxicity tests;
  • A series of workshops supported by NICEATM and ICCVAM agencies that drafted recommendations for use of an in vitro test with potential to replace animal use for pertussis vaccine testing.

Links to this report and all past ICCVAM annual and biennial reports are available at

NICEATM reaches new audience at ACS

NICEATM continued to reach out to new audiences with a presentation at the 252nd American Chemical Society National Meeting, held August 21-25 in Philadelphia. Shannon Bell, Ph.D., computational toxicologist for NICEATM support contractor ILS, spoke on computational methods for predicting toxicity developed by NICEATM in the session “Innovations in Human Health Exposure and Risk Assessment.” Bell summarized the needs for computational toxicology tools and resources identified in the February 2016 NICEATM workshop “In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making.” A NICEATM web resource for facilitating chemical evaluations that will address needs identified in the workshop is currently under development and scheduled for launch in 2017. Bell gave a talk on a related topic at the Annual Meeting of the Society for Industrial and Applied Mathematics in Boston in July. These presentations are part of NICEATM’s efforts to bring a broader range of expertise to the development of alternative test methods.

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Director of Office of Liaison, Policy, and Review and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley