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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterJanuary 2017

NTP Interagency Center for the Evaluation of Alternative Toxicological Methods

By Catherine Sprankle

New EPA guidance for testing pesticides will reduce animal testing

On November 30, the U.S. Environmental Protection Agency (EPA) published "Guidance for Waiving Acute Dermal Toxicity Tests for Pesticide Formulations and Supporting Retrospective Analysis." The new guidance expands the potential for data waivers for acute dermal studies and includes a policy statement to waive all acute lethality dermal studies for formulated pesticide products. EPA expects this waiver guidance to reduce the use of laboratory animals by up to 2,500 or more each year. The EPA Office of Pesticide Programs and NICEATM conducted a retrospective analysis of acute oral and dermal studies that formed the basis for the new guidance. The guidance document is available on the EPA website.

Allen to receive SOT Enhancement of Animal Welfare Award

David Allen has been named the recipient of the Society of Toxicology (SOT) 2017 Enhancement of Animal Welfare Award. Allen, of Integrated Laboratory Systems, Inc., is principal investigator on the NICEATM support contract. He is also past president of SOT’s In Vitro and Alternative Methods specialty section and current president of the American Society for Cellular and Computational Toxicology.

The Enhancement of Animal Welfare Award is presented annually to an SOT member to recognize contributions made towards the development and application of methods that replace, refine, or reduce the need for experimental animals. Allen will receive the award at the annual SOT meeting in March 2017 in Baltimore, MD.

NICEATM-EPA AR pathway article named Editors’ Choice

NICEATM Deputy Director Nicole Kleinstreuer is the lead author on a paper describing an androgen receptor pathway model that incorporates 11 high throughput screening assays. “Development and Validation of a Computational Model for Androgen Receptor Activity,” published online on November 18 in Chemical Research in Toxicology, has been selected as an ACS Editor’s Choice Article. This selection was based on recommendations by the scientific editors of ACS journals around the world. With this designation, the article becomes open access, meaning it can viewed by anyone regardless of institutional affiliation or subscription status.

  • Kleinstreuer NC et al. 2016. Development and validation of a computational model for androgen receptor activity [published online ahead of print 18 November 2016]. Chemical Research in Toxicology. Available:

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The Update Newsletter is produced by NTP Office of Liaison, Policy, and Review. The text is not copyrighted and can be reprinted without permission. If you use parts of the Update Newsletter in your publication, we ask that you provide us with a copy for our records. We welcome your comments and suggestions.

Director of Office of Liaison, Policy, and Review and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley