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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterDecember 2018

The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods

By Catherine Sprankle

Webinar Will Describe Non-animal Approaches for Inhalation Toxicity Testing

A webinar on “Non-animal Approaches for Inhalation Toxicity Testing” will be presented on January 22, 2019, from 1:00 to 2:30 p.m. The webinar is organized by NICEATM on behalf of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). The webinar is free and open to the public, but registration is required to attend. The preliminary agenda and additional information about presentations will be posted on the NTP website when available.

ICCVAM promotes the development and validation of toxicity testing methods that protect human health and the environment while replacing, reducing, or refining animal use. ICCVAM also provides guidance to test method developers and facilitates collaborations that promote the development of new test methods. To address these goals, ICCVAM holds annual Communities of Practice webinars that focus on current topics in alternative methods for toxicity testing.

The upcoming webinar will provide an overview of several ongoing collaborative efforts associated with acute and subchronic inhalation toxicity testing, with emphasis on available human cell-based and in silico methodologies, considerations of dosimetry, and developing technologies that could provide predictive test methods in the future. The webinar will also present a case study describing a source-to-outcome approach that uses in vitro and in silico methods to refine inhalation risk assessment for point of contact toxicity.

Recent NICEATM Publications

  • A paper published online November 10 summarizes the initial information-gathering efforts of the NTP Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) initiative. This effort provides a basis for future SEAZIT activities to promote more consistent practices among researchers using zebrafish embryos for toxicity evaluation.
    Hamm et al. 2018. Characterizing sources of variability in zebrafish embryo screening protocols. https://www.altex.org/index.php/altex/article/view/997
  • A review article by the ICCVAM Skin Sensitization Workgroup and co-authors from U.S. federal agencies identifies the standards, test guidelines, or guidance documents that are applicable to satisfy U.S. agency information needs relevant to skin sensitization hazard.
    Strickland et al. 2018. Skin sensitization testing needs and data uses by U.S. regulatory and research agencies. https://link.springer.com/epdf/10.1007/s00204-018-2341-6
  • A review article by the ICCVAM Ocular and Dermal Irritation Workgroup and co-authors from U.S. federal agencies surveys U.S. agency information needs relevant to ocular and dermal irritation hazard.
    Choksi et al. 2018. United States regulatory requirements for skin and eye irritation testing. https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1540494
  • NICEATM Deputy Director Nicole Kleinstreuer collaborated with scientists at several universities and the U.S. Department of Veterans Affairs to develop and evaluate computer simulation models of particle deposition in human and mouse airways, resources that will support pharmacokinetic and toxicokinetic studies of inhaled substances.
    Kolanjiyil et al. 2018. Mice-to-men comparison of inhaled drug-aerosol deposition and clearance. https://www.sciencedirect.com/science/article/pii/S1569904818302258

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The Update Newsletter is produced by NTP Office of Liaison, Policy, and Review. The text is not copyrighted and can be reprinted without permission. If you use parts of the Update Newsletter in your publication, we ask that you provide us with a copy for our records. We welcome your comments and suggestions.

Director of Office of Liaison, Policy, and Review and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley