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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterMay 2019

The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods

By Catherine Sprankle

ASCCT Annual Meeting September 25-26

The eighth annual meeting of the American Society for Cellular and Computational Toxicology (ASCCT) will be September 25-26 in Gaithersburg, Maryland. The meeting will focus on computational toxicology, with NICEATM Deputy Director Nicole Kleinstreuer scheduled to give a plenary presentation. Other agenda items include a panel discussion on data and methodology quality and transparency, a social reception and networking event, and a mentoring activity and awards for young scientists.

Abstracts are being accepted for oral and poster presentations. Abstracts for oral presentations should be submitted by June 28; the poster abstract deadline is August 1. Abstracts are welcome on all topics related to cellular and computational toxicology.

Registration, Comments Deadline May 10 for ICCVAM Public Forum

On behalf of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), NICEATM will convene the ICCVAM Public Forum on Thursday, May 23, at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland. The ICCVAM Public Forum is held annually to share information and facilitate direct communication of ideas and suggestions to ICCVAM from stakeholders. This year’s meeting will include presentations by NICEATM and ICCVAM members on current activities related to the development and validation of alternative test methods and approaches, including activities relevant to implementation of the strategic roadmap for establishing new approaches to evaluate the safety of chemicals and medical products in the United States.

Preregistration to attend the meeting in person closes Friday, May 10. Prepared statements on topics relevant to the meeting should also be submitted by that date. Registration for webcast viewing will be open through the end of the meeting on May 23. Information about the meeting and for submitting public statements are available on the NTP website

Recent NICEATM and ICCVAM Publications

  • A recent publication co-authored by ICCVAM co-chair Anna Lowit, U.S. Environmental Protection Agency, describes a retrospective analysis of toxicity data for 119 pesticides with publicly available ecological risk assessments. The analysis indicated that in most cases avian risk can be assessed without conducting the currently required sub-acute dietary test, which may provide an opportunity for reduction of animal use.
  • NICEATM Deputy Director Nicole Kleinstreuer is a co-author on a 2017 workshop report that provides recommendations for the development and validation of alternatives to animal testing and identifies steps to facilitate regulatory acceptance. The workshop, which was organized by the Netherlands National Institute for Public Health and the Environment and the German Federal Institute for Risk Assessment, focused on the drivers and barriers to implementing innovative approaches that can replace, reduce, or refine animal use for regulatory toxicology.

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The Update Newsletter is produced by NTP Office of Liaison, Policy, and Review. The text is not copyrighted and can be reprinted without permission. If you use parts of the Update Newsletter in your publication, we ask that you provide us with a copy for our records. We welcome your comments and suggestions.

Director of Office of Liaison, Policy, and Review and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley