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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterSeptember 2019

The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

By Catherine Sprankle

SACATM to Meet September 19-20

The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet on September 19-20 at the Crowne Plaza Crystal City in Arlington, Virginia. Preliminary agenda items for the upcoming meeting include:

  • New approaches to the principles and practice of validation
  • Developing a next generation data infrastructure to support the development and implementation of new approach methodologies (NAMs) for complex endpoints
  • Translational impact and human relevance of NAMs

SACATM meets annually to advise NICEATM, the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and the director of the National Institute of Environmental Health Sciences regarding statutorily mandated duties of ICCVAM and activities of NICEATM.

The SACATM meeting is open to the public and attendance is free. Registration is open to attend the meeting in person or view the webcast. Those wishing to attend in person and/or submit public comments should register to do so by September 12.

NICEATM Activities at ASCCT Annual Meeting

The American Society for Cellular and Computational Toxicology (ASCCT) will hold its annual meeting on September 24-26 at the Hilton Washington DC North in Gaithersburg, MD. The theme of the meeting is “Computational Toxicology: Peeking into the Clouds While Keeping Our Feet on Solid Ground.” Program highlights include a mentoring event, poster session, and hands-on computational tools training session. The online registration deadline is September 13.

NICEATM Deputy Director Nicole Kleinstreuer is a featured speaker at the meeting, with a presentation on “The March Toward Big Data in Toxicology: Striking a Balance Between Machine Learning and Mechanistic Modeling.” Shannon Bell, ILS (contractor supporting NICEATM) will give an oral presentation titled “Good Decisions Require Good Data: Creating Curated and Structured Resources for Toxicology.” NICEATM will also have two presentations at the poster session. More information about NICEATM activities at ASCCT is available on the NTP website.

Recent Publication

A review article coauthored by NICEATM Deputy Director Kleinstreuer and coauthors at the U.S. Environmental Protection Agency describes the use of gene expression biomarkers to identify endocrine-disrupting chemicals. This approach can identify both androgen and estrogen receptor agonists and antagonists with over 90% accuracy in microarray data derived from human breast or prostate cancer cell lines. Predictions generated with this approach can help prioritize chemicals with the greatest risk of potential adverse outcomes in the endocrine systems of animals and people.

Corton et al. 2019. Identification of potential endocrine disrupting chemicals using gene expression biomarkers. Toxicol Appl Pharmacol. https://doi.org/10.1016/j.taap.2019.114683

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The Update Newsletter is produced by NTP Office of Liaison, Policy, and Review. The text is not copyrighted and can be reprinted without permission. If you use parts of the Update Newsletter in your publication, we ask that you provide us with a copy for our records. We welcome your comments and suggestions.

Director of Office of Liaison, Policy, and Review and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley