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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterFebruary 2020

The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

By Catherine Sprankle

Slides available from ICCVAM webinar on animal-free affinity reagents

Slides from the January 21 ICCVAM Communities of Practice webinar on “Use of Animal-free Affinity Reagents” are available on the NTP website at https://ntp.niehs.nih.gov/go/commprac-2020.

In this webinar, Alejandra Solache of Abcam presented an overview of production, use, and characteristics of monoclonal and polyclonal antibodies. Rebecca Clewell of 21st Century Tox Consulting summarized a recent review by a working group of the Scientific Advisory Committee of the European Union Reference Laboratory for Alternatives to Animal Testing on the scientific validity and benefits of animal-free technologies to produce affinity reagents.

Save the date for two upcoming ICCVAM public events:

  • Exhibitor-hosted session at the Society of Toxicology Annual Meeting, “ICCVAM at 20: Looking Back and Looking Forward,” Tuesday, March 17, 3:00-4:00 p.m., Anaheim Convention Center Room 206B
  • ICCVAM Public Forum, Thursday, May 21, Natcher Conference Center, National Institutes of Health, Bethesda, MD

Webinar demonstrates NICEATM tool for predicting acute oral toxicity

A video recording and slides are available from a January 22 webinar titled “CATMoS: Development and Use of the Collaborative Acute Toxicity Modeling Suite,” presented by the PETA International Science Consortium (PETA-ISC). Links to recordings of all webinars in the PETA-ISC series on “Use of New Approach Methodologies in Risk Assessment” are available at https://www.piscltd.org.uk/nam-webinars/.

In this webinar, NICEATM Acting Director Nicole Kleinstreuer and Kamel Mansouri, ILS (contractor supporting NICEATM), discussed development of CATMoS, a free resource for screening organic chemicals for acute oral toxicity. Predictions generated by CATMoS compare favorably with performance characteristics of the in vivo acute oral toxicity test. Kleinstreuer and Mansouri also demonstrated how to use the modeling suite to generate acute oral toxicity predictions.

Recent publications

  • A paper now available online from ALTEX summarizes discussions on the status of development and use of animal-free recombinant antibodies and their potential to replace antibodies derived from animals from a December meeting organized by NICEATM and the PETA International Science Consortium, Ltd. Co-authors of the paper include Acting NTP Biomolecular Screening Branch Chief Warren Casey and David Allen, ILS.
    Groff et al. 2020. Increasing the use of animal-free recombinant antibodies. ALTEX. https://doi.org/10.14573/altex.2001071.
  • NICEATM Acting Director Nicole Kleinstreuer is a co-author of a recent paper describing an in vitro method for eye irritation testing. A multilaboratory validation study indicated that the Vitrigel-Eye Irritancy Test could be a useful alternative to animal testing for distinguishing test chemicals that are ocular non-irritants from irritants.
    Kojima et al. 2019. Multi-laboratory validation study of the Vitrigel-Eye Irritancy Test method as an alternative to in vivo eye irritation testing. Altern Lab Anim 47(3-4):140-157. https://doi.org/10.1177/0261192919886665.

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The Update Newsletter is produced by NTP Office of Liaison, Policy, and Review. The text is not copyrighted and can be reprinted without permission. If you use parts of the Update Newsletter in your publication, we ask that you provide us with a copy for our records. We welcome your comments and suggestions.

Director of Office of Liaison, Policy, and Review and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley