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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterMarch 2020

The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

By Catherine Sprankle

NICEATM and ICCVAM activities at SOT

A webpage summarizing NICEATM activities at the March 15-19 Society of Toxicology (SOT) annual meeting is available on the NTP website at The webpage also lists activities of members of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), which NICEATM supports. Please refer to this page as you plan your SOT itinerary.

NICEATM and ICCVAM will have a strong presence at SOT. A session sponsored by the National Institute of Environmental Health Sciences will celebrate the 20th anniversary of the establishment of ICCVAM. NICEATM and ICCVAM are presenting at three continuing education sessions and an ancillary meeting; NICEATM is presenting at three platform sessions and six poster sessions; and ICCVAM members are coauthors on abstracts being presented at one platform session and nine poster sessions. ILS staff, in support of NICEATM, will offer an overview and hands-on tutorial on the Open Structure-Activity/Property Relationship App (OPERA) and the Integrated Chemical Environment (ICE) web tools Monday through Wednesday at the NTP ToxExpo booth.

Paper describes predictive model for androgenic activity

A paper now available online from Environmental Health Perspectives describes a worldwide consortium led by the U.S. Environmental Protection Agency to develop models to virtually screen chemicals for their potential androgenic activity. The paper was coauthored by Acting NICEATM Director Nicole Kleinstreuer; the first author is Kamel Mansouri, ILS (contractor supporting NICEATM). Predictions generated by the consensus model developed for the project are available in the NICEATM Integrated Chemical Environment (

Mansouri et al. 2020. CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity. Environ Health Perspect.

Paper describes framework for evaluation of NAMs

Former NICEATM Director Warren Casey and NICEATM Acting Director Nicole Kleinstreuer are co-authors on a paper that describes a framework for evaluating new approach methodologies (NAMs). The goal of this framework, developed by a multi-stakeholder group of industry, academic, and regulatory experts, is to provide a structure to collect relevant information to build confidence that will accelerate, facilitate and encourage development of NAMs that can be used within appropriate regulatory contexts.

Parish et al. 2020. An evaluation framework for new approach methodologies for human health safety assessment. Reg Toxicol Pharmacol.

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The Update Newsletter is produced by NTP Office of Liaison, Policy, and Review. The text is not copyrighted and can be reprinted without permission. If you use parts of the Update Newsletter in your publication, we ask that you provide us with a copy for our records. We welcome your comments and suggestions.

Director of Office of Liaison, Policy, and Review and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley