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RoC Review of Helicobacter pylori (H. pylori): Chronic Infection

3D rendering of Helicobacter pylori

Substance Overview

Status: Cancer hazard evaluation for potential listing in the Report on Carcinogens (RoC)

Primary Uses or Exposures

  • A gram negative, multi-flagellated bacterium that colonizes the stomach and causes peptic ulcer.
  • Spread by person-to-person contact especially among family members or in crowded living conditions or poor sanitation/hygiene.
  • Routes of exposure include: oral-oral, fecal-oral and possibly from contaminated water. The bacterium has been detected in surface, ground, and well water in the United States.
  • Approximately 36% of the total population are infected with H. pylori.


Documents for H. pylori
Date Document
Jan 19, 2012 Federal Register notice requesting public comment on nominated substances (PDF HTML)
Mar 15, 2016 RoC Concept
May 01, 2018 RoC Monograph - Peer review draft
May 11, 2018 Federal Register notice requesting public comment on the draft monograph (PDF HTML)
Sep 12, 2018 RoC Monograph - Revised draft
Oct 26, 2018 RoC Monograph - Final

Meetings & Events

Listing of related events
Date Event Event Type Materials
Apr 11, 2016

NTP Board of Scientific Counselors Meeting

Board of Scientific Counselors
Oct 09, 2018

NTP Board of Scientific Counselors Meeting

Board of Scientific Counselors

Supplemental materials for events, meetings, and workshops prior to 2016 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials for the following meeting.

Note on Accessibility: Persons with disabilities or using assistive technology may find some documents are not fully accessible. For assistance, email us or use our contact form and identify the documents/pages for which access is required. We will assist you in accessing the content of these files. NIEHS has helpful information on accessibility.