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Mind the Gaps: Prioritizing Activities to Meet Regulatory Needs for Acute Systemic Lethality

October 30-31, 2019
Porter Neuroscience Research Center
National Institutes of Health
Bethesda, Maryland, USA

Register to attenddeadline October 24

Agenda (October 15)

Acute systemic toxicity tests are the most commonly performed type of safety test worldwide. Participants in this workshop will consider approaches available to assess acute lethality associated with chemicals and chemical mixtures, with the purpose of designing comprehensive strategies to predict toxicity while avoiding animal tests. The envisioned specific areas for discussion will include:

  • Defining how to calculate the LD50 of a chemical mixture/formulated product
  • Identifying gaps where model (or assay) development or optimization is needed
  • Understanding regulatory needs for model (or assay) outputs
  • Pinpointing the types of mechanistic information that would be useful
  • Establishing the feasibility of using artificial intelligence in model development

The workshop is being organized by NICEATM and the Physicians Committee for Responsible Medicine.

Workshop Information

The workshop is open to the public, free of charge, with attendance limited only by space available. Those attending should review information for visitors on the National Institutes of Health website.

Individuals with disabilities who need accommodation to participate in this event should contact Dr. Elizabeth Maull at telephone: (984) 287–3157 or email: TTY users should contact the Federal TTY Relay Service at (800) 877–8339. Requests should be made at least five business days in advance of the event.