Presentations at SOT 2019

ICCVAM member Suzanne Fitzpatrick (FDA) was a course co-chair.

ICCVAM co-chair Anna Lowit (EPA) was a course co-chair.

Presentation: U.S. EPA Perspective on Implementation of Toxicokinetics in Agrochemical Safety Assessments
Presenter: Lowit A

Presentation: Advances in Nonanimal Alternatives to Dermal and Ocular Toxicity Testing
Presenter: Kleinstreuer N

Roadmap Overview and ICCVAM Activities
Warren Casey, NIEHS

NTP Activities
Brian Berridge, NIEHS

FDA Activities
Suzanne Fitzpatrick, FDA Center for Food Safety and Applied Nutrition

EPA Activities
Anna Lowit, EPA Office of Pesticide Programs

DoD Activities
Emily Reinke, U.S. Army Public Health Center

Nicole Kleinstreuer (NIEHS) was a session chair

Abstract Number 1018: IVIVE Tools for Risk Assessment
Presenter: Kleinstreuer N

Abstract Number 1745/Poster P121: Adding Context to Tox21/ToxCast Data: Linking In Vitro Assays to Toxicity Outcomes
Authors: Karmaus AL, Bell SM, Allen DG, Casey WM, Kleinstreuer NC
Recognized as a Top 10 Risk Assessment Abstract for the 2019 Annual Meeting, SOT Risk Assessment Specialty Section
Karmaus et al poster — Text version of Karmaus et al poster

Abstract Number 1747/Poster P123: The Integrated Chemical Environment: Tools and Data to Support Toxicity Assessments
Authors: Bell SM, Phillips J, Cariello N, Ceger P, Chang X, Hermes F, Karmaus AL, Mansouri K, McAfee E, Rai R, Allen DG, Casey WM, Kleinstreuer NC
Bell et al poster — Text version of Bell et al poster

Abstract Number 2453/Poster P868: Prevalidation of the OptiSafe Ocular Irritation Assay for the Detection of Ocular Corrosives
Authors: Lebrun SJ, Choksi N, Daniel A, Allen D, Casey W

Nicole Kleinstreuer (NIEHS) was a panel participant

Abstract Number 2469/Poster P884: Using the Monocyte Activation Test for Medical Devices
Authors: Allen DG, Clippinger A, Morefield S, Casey WM, Ghosh C, Goode J, Brown J
Allen et al poster — Text version of Allen et al poster

Abstract Number 2485/Poster P900: Exploring Current Read-across Applications and Needs Among U.S. Federal Agencies
Authors: Mumtaz M, Lizarraga L, Rua D, Allen DG, Daniel A, Fitzpatrick SC, Garcia-Reyero N, Gordon J, Hakkinen P, Howard AS, Karmaus AL, Matheson J, Ruiz P, Scarano L, Kleinstreuer NC, Patlewicz G
Please note: This is a duplicate of Abstract Number 1771, which was not presented at the meeting.
Mumtaz et al poster — Text version of Mumtaz et al poster

Agnes Karmaus (ILS, contractor supporting NICEATM) and Nicole Kleinstreuer (NIEHS) were session co-chairs

Abstract Number 2562: Derivation of a Dataset for Modeling Acute Oral Toxicity and Variability Assessment of In Vivo LD50 Data
Presenter: Kleinstreuer N

Abstract Number 2563: International Collaboration to Build Predictive Models for Acute Oral Toxicity
Presenter: Mansouri K

Abstract Number 3207: Current and Future Opportunities for U.S. Regulatory Application of Developmental Toxicity NAMs
Presenter: Kleinstreuer N

Abstract Number 3138/Poster P886: An Open-source, Generalized Workflow for IVIVE Analysis
Authors: Chang X, Mansouri K, Hermes F, Phillips J, Bell SM, Allen DG, Casey WM, Kleinstreuer NC
Chang et al poster — Text version of poster

Presentation: QSAR Modeling to Support Regulatory Purposes
Presenter: Mansouri K

Abstract Number 3401/Poster P194: Mixture-based Modeling of Chemical Ocular Toxicity Based on US EPA Hazard Categories
Authors: Sedykh A, Choksi N , Allen D , Kleinstreuer N , Casey W, Shah RR
Sedykh et al poster

Abstract Number 3514/Poster P310: Defined Approach for Detection of Eye Irritants and Corrosives for Pesticide Formulations
Authors: Choksi N, Clippinger AJ, Gehen S, Corvaro M, Ng S, Kolle SN, van Cott A, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen D
Choksi et al poster — Text version of Choksi et al poster

Abstract Number 1080: What’s So Special about 3D Spheroid Cultures? Exploration of Best Practices with Human Hepatocyte Models over Time in Culture
Authors: Lavrich KS, Ramaiahgari, DeVito MJ, Paules RS, Ferguson SS

Abstract Number 1108/Poster P129: Zebrafish Locomotor Responses Reveal That Irritant Effects of Biomass Smoke Are Influenced by Fuel Type, Burn Conditions, and Byproduct Chemistry
Authors: Martin WK, Padilla S, Kim Y, Hays MD, Hunter DL, Hazari MS, DeMarini DM, Gilmour MI, Farraj AK

Abstract Number 1367/Poster P424: Screening for Developmental Neurotoxicity at the National Toxicology Program: The Future Is Here
Authors: Behl M, Ryan K, Hsieh J, Parham F, Shapiro AJ, Collins BJ, Sipes NS, Birnbaum LS, Bucher JR, Foster PM, Walker NJ, Paules RS

Abstract Number 1376/Poster P433: Assessment of Neurotoxic Potential of 90 Blinded Compounds Using Zebrafish Embryos
Authors: Quevedo C, Behl M, Ryan K, Paules RS, Alday A, Muriana A, Alzualde A

Abstract Number 1379/Poster P436: Assessing the Developmental Toxicity and Developmental Neurotoxicity of 26 Organophosphorus Pesticides Using a Zebrafish (Danio rerio) Larval Assay
Authors: Padilla S, Waalkes M, Hunter DL, Hedge J, Jarema K

Abstract Number 1470/Poster P552: Transient Alanine Aminotransferase Increases following Acetaminophen Treatment in Rats
Authors: Mattes WB, Regev A, Church RJ, Watkins PB, Avigan M, Mendrick D, Greenhaw JJ, Shi Q

Abstract Number 1287/Poster P316: Transcriptomic Profiling of the Inter-Individual Variability of Chemical-Induced Cellular Stress Response Activation Using a Large Panel of Primary Human Hepatocyte Donors
Authors: Niemeijer M, Huppelschoten S, Baze A, Parmentier C, Paules RS, Richert L, van de Water B

Abstract Number 1630: A View across the Atlantic: Synopsis and Opportunities
Author: Fitzpatrick S

Abstract Number 1159/Poster P183: Examination of the Avian Acute Oral versus Sub-Acute Dietary Testing in Ecological Risk Assessment
Authors: Hilton GM, Odenkirchen E, Panger M, Waleko G, Lowit A, Clippinger AJ

Abstract Number 2322/Poster P734: Oncogenic KRAS Occurs after Prolonged In Vitro Arsenite Exposure of Human Prostate Epithelial Cells
Authors: Merrick A, Phadke D, Shah R, Pelch K, Auerbach S, Paules R, DeVito M, Waalkes M, Tokar E

Abstract Number 2342/Poster P754: Systematic Review on the Effects of a 0.5 µg/dL Blood Lead Level in Children and Pregnant Women
Authors: Dolan L, Flannery B, Fitzpatrick S

Abstract Number 2425/Poster P840: Increasing Confidence in the EASA Skin Sensitization Assay Using a Measurement Science Approach
Authors: Gordon J, Uhl R, Toman B, Elliot J, Petersen E

Abstract Number 2440/Poster P855: The Power of Resolution: Contextualized Understanding of Chemical-Biological Interactions
Authors: Ferguson SS, Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick B, Paules RS

Abstract Number 1827/Poster P208: Gaining Insights to Molecular Mechanisms of Combined Air Pollutants Exposures Using PBPK Models and Systems Biology Approaches
Authors: Ruiz P, Emond C, Mumtaz M

Presentation: Relevance of the Delaney Clause to the 21st-Century Regulatory Issues
Author: Fitzpatrick S

Abstract Number 2508: U.S. EPA Initiative to Implement Alternatives to Acute Systemic Toxicity: An Update
Author: Lowit A

Donna Mendrick (FDA) was a session chair

Abstract Number 2561: Regulatory Progress on Acute Toxicity Testing
Author: Lowit A

Abstract Number 2597: Electronic Nicotine Delivery Systems in Context: The US FDA Perspective
Author: Hung P

Abstract Number 2622: 3D Hepatocyte Spheroid Models in High-Throughput Transcriptomics and Benchmark Concentration Analysis for Predictive Liver Toxicology Screening
Authors: Ramaiahgari SC, Auerbach SS, Saddler TO, DeVito MJ, Merrick AB, Paules RS, Ferguson SS

Abstract Number 2762/Poster P248: An Integrated Approach to Evaluate Common Mechanisms of Toxicity in Pesticides to Support Cumulative Risk Assessment
Authors: Leonard J, Nelms M, Craig E, Dobreniecki S, Perron M, Pope-Varsalona H, Lowit A, Tan C

Abstract Number 3178/Poster P763: Development of a Zebrafish S1500+ Sentinel Gene Set for High-Throughput Transcriptomics
Authors: Balik-Meisner M, Phadke D, Mav D, Everett L, Shah R, Merrick BA, Paules R

Abstract Number 2795/Poster P281: Development of a Joint DOD Roadmap to Promote the Use of New Approach Methodologies in Rapid Chemical Hazard Assessment
Authors: Perkins E, Burgoon L, Garcia-Reyero N, Gearhart JM, McAtee M, Ott D, Pangburn H, Reinke E, Stolle L

Abstract Number 2781/Poster P285: Use of Dog Studies in U.S. FDA’s Safety Assessments for Food Additives and Color Additives
Authors: Anyangwe N, Fitzpatrick S, Flannery B, Mattia A, Schaefer H, Tyler T, Whiteside C

Abstract Number 3069/Poster P606: Physicochemical Characterization and In Vitro Toxicity of Emissions from a 3D Printer
Authors: Farkas M, Stefaniak A, Knepp A, Bowers L, Jackson S, Mandler W, Stueckle T, Friend S, Qi C, Hammond D, Thomas T, Matheson J, Qian Y

Abstract Number 2640/Poster P105: Chemical Contaminants in Children's Foods: A Review of Recent Literature
Authors: Schaefer H, Fitzpatrick S, Flannery B