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Corrositex Test Method for Dermal Corrosivity Testing

ICCVAM convened an independent peer review panel meeting in 1999 to evaluate Corrositex® for the identification of potential skin corrosives. This assay tests if a substance can pass through a biobarrier by diffusion, erosion, or destruction.

The panel concluded that:

  • Corrositex® is useful for certain testing circumstances, such as testing performed to comply with DOT regulations.
  • Corrositex® can serve as a stand-alone test for evaluating the corrosivity or noncorrosivity of acids, bases, and acid derivatives and can replace the use of animals.

Corrositex® is accepted as an alternative to a procedure specified in the DOT Hazardous Materials Regulations (DOT-SP 10904) for packing group classification of corrosive materials.

Peer Review Panel Report

Corrositex®: An In Vitro Test Method for Assessing Dermal Corrosivity Potential of Chemicals
The Results of an Independent Peer Review Evaluation Coordinated by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)
(NIH Publication No. 99-4495, June 1999)

Agency Responses to Panel Recommendations

Recommendations were originally communicated to Federal agencies in letters from NIEHS Director Dr. Kenneth Olden to the agency heads. Links to the responses from agency officials can be found below:

Other Related Documents and Sites

In vitro membrane barrier methods such as Corrositex® are accepted internationally via OECD Test Guideline 435. Read about this test guideline and view other related documents and sites below: