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Testing Status of Bisphenol AF 08002

 

CASRN: 1478-61-1

Formula: C15-H10-F6-O2

Synonyms/Common Names

  • 2,2-Bis(4-hydroxyphenyl)hexafluoropropane
  • 2,2-Bis(4-hydroxyphenyl)perfluoropropane
  • BPA-F
  • BP-AF
  • BPA F
  • BPAF
  • Hexafluorobisphenol A
  • 4,4’-(Hexafluoroisopropylidene)diphenol
  • Phenol, 4,4'-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis-

Short-Term Toxicity

  • 5 days (Gavage)  (C08002)  Data in Review 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Female rats: 0, 8, 16, 31.25, 62.5, 125, 250, 500, or 1000 mg/kg; N=4. Male rats: 0, 8, 16, 31.25, 62.5, 125, 250, 500, or 1000 mg/kg; N=4.

Modified One-Generation

  • Dose Range Finding (Dosed-Feed)  (MOG08002)  Completed 
    • Citation: National Toxicology Program (NTP). 2022. NTP developmental and reproductive toxicity technical report on the modified one-generation study of bisphenol AF (CASRN 1478-61-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats with prenatal, reproductive performance, and subchronic assessments in F1 offspring. Research Triangle Park, NC: National Toxicology Program. DART Report 08. https://doi.org/10.22427/NTP-DART-08
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 937.5, 1875, 3750, or 7500 ppm.
  • Developmental Toxicity (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Citation: National Toxicology Program (NTP). 2022. NTP developmental and reproductive toxicity technical report on the modified one-generation study of bisphenol AF (CASRN 1478-61-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats with prenatal, reproductive performance, and subchronic assessments in F1 offspring. Research Triangle Park, NC: National Toxicology Program. DART Report 08. https://doi.org/10.22427/NTP-DART-08
    • Citation: Waidyanatha S, Collins BJ, Cunny H, Aillon K, Riordan F, Turner K, McBride S, Betz L, Sutherland V. An investigation of systemic exposure to bisphenol AF during critical periods of development in the rat. Toxicol Appl Pharmacol. 2021 Jan 15;411:115369. doi: https://doi.org/10.1016/j.taap.2020.115369. Epub 2020 Dec 15.
    • Rats: Harlan Sprague-Dawley
  • F0 Generation (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Citation: National Toxicology Program (NTP). 2022. NTP developmental and reproductive toxicity technical report on the modified one-generation study of bisphenol AF (CASRN 1478-61-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats with prenatal, reproductive performance, and subchronic assessments in F1 offspring. Research Triangle Park, NC: National Toxicology Program. DART Report 08. https://doi.org/10.22427/NTP-DART-08
    • Citation: Waidyanatha S, Collins BJ, Cunny H, Aillon K, Riordan F, Turner K, McBride S, Betz L, Sutherland V. An investigation of systemic exposure to bisphenol AF during critical periods of development in the rat. Toxicol Appl Pharmacol. 2021 Jan 15;411:115369. doi: https://doi.org/10.1016/j.taap.2020.115369. Epub 2020 Dec 15.
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 338, 1125, or 3750 ppm.
  • Fertility Assessment (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Citation: National Toxicology Program (NTP). 2022. NTP developmental and reproductive toxicity technical report on the modified one-generation study of bisphenol AF (CASRN 1478-61-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats with prenatal, reproductive performance, and subchronic assessments in F1 offspring. Research Triangle Park, NC: National Toxicology Program. DART Report 08. https://doi.org/10.22427/NTP-DART-08
    • Citation: Waidyanatha S, Collins BJ, Cunny H, Aillon K, Riordan F, Turner K, McBride S, Betz L, Sutherland V. An investigation of systemic exposure to bisphenol AF during critical periods of development in the rat. Toxicol Appl Pharmacol. 2021 Jan 15;411:115369. doi: https://doi.org/10.1016/j.taap.2020.115369. Epub 2020 Dec 15.
    • Rats: Harlan Sprague-Dawley
  • Maternal Transfer (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Citation: National Toxicology Program (NTP). 2022. NTP developmental and reproductive toxicity technical report on the modified one-generation study of bisphenol AF (CASRN 1478-61-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats with prenatal, reproductive performance, and subchronic assessments in F1 offspring. Research Triangle Park, NC: National Toxicology Program. DART Report 08. https://doi.org/10.22427/NTP-DART-08
    • Citation: Waidyanatha S, Collins BJ, Cunny H, Aillon K, Riordan F, Turner K, McBride S, Betz L, Sutherland V. An investigation of systemic exposure to bisphenol AF during critical periods of development in the rat. Toxicol Appl Pharmacol. 2021 Jan 15;411:115369. doi: https://doi.org/10.1016/j.taap.2020.115369. Epub 2020 Dec 15.
    • Rats: Harlan Sprague-Dawley
  • 13-Week Subchronic (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Citation: National Toxicology Program (NTP). 2022. NTP developmental and reproductive toxicity technical report on the modified one-generation study of bisphenol AF (CASRN 1478-61-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats with prenatal, reproductive performance, and subchronic assessments in F1 offspring. Research Triangle Park, NC: National Toxicology Program. DART Report 08. https://doi.org/10.22427/NTP-DART-08
    • Citation: Waidyanatha S, Collins BJ, Cunny H, Aillon K, Riordan F, Turner K, McBride S, Betz L, Sutherland V. An investigation of systemic exposure to bisphenol AF during critical periods of development in the rat. Toxicol Appl Pharmacol. 2021 Jan 15;411:115369. doi: https://doi.org/10.1016/j.taap.2020.115369. Epub 2020 Dec 15.
    • Rats: Harlan Sprague-Dawley

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous; Gavage; Intravenous)  (K08002)  Completed 
    • Citation: Waidyanatha S, Mathews JM, Patel PR, Black SR, Snyder RW, Fennell TR. Disposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration. Xenobiotica. 2015;45(9):811-9. doi: 10.3109/00498254.2015.1021732. Epub 2015 Jun 12.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
    • Dose: 3.4, 34, 340 mg/kg. 34 mg/kg. 34 mg/kg [R,M].
  • 1 day Preliminary Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (K08002B)  Completed 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
    • Dose: 3.4 mg/kg. 34 mg/kg. 34, 340 mg/kg.
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (K08002C)  Completed 
    • Citation: Waidyanatha S, Black SR, Aillon K, Collins B, Patel PR, Riordan F, Sutherland V, Robinson VG, Fernando R, Fennell TR. Toxicokinetics and bioavailability of bisphenol AF following oral administration in rodents: A dose, species, and sex comparison. Toxicol Appl Pharmacol. 2019 Jun 15;373:39-47. doi: https://doi.org/10.1016/j.taap.2019.04.015. Epub 2019 May 3.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 34 mg/kg. 34 mg/kg [R,M]. 34, 110 and 340 mg/kg.
  • Repeat (7 days) Toxicokinetic Study (Dosed-Feed)  (K08002D)  Completed 
    • Citation: Waidyanatha S, Black SR, Croutch CR, Collins BJ, Silinski MAR, Kerns S, Sutherland V, Robinson VG, Aillon K, Fernando RA, Mutlu E, Fennell TR. Comparative toxicokinetics of bisphenol S and bisphenol AF in male rats and mice following repeated exposure via feed. Xenobiotica. 2020 Oct 6:1-12. doi: 10.1080/00498254.2020.1829171. Epub ahead of print.Pubmed Abstract
    • Male Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1/N
    • Dose: 338, 1125, 3750 ppm [R,M].

Genetic Toxicology

  • 20 weeks Micronucleus (Dosed-Feed)  (G08002B)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (G08002)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 to PND 96 Developmental Immunotoxicity (Dosed-Feed)  (I08002)  On Test 
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 250, 500, or 1000 ppm.
  • Utero-Lactational (In Utero)  (R08002)  Completed 
    • Rats: Harlan Sprague-Dawley

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T08002)  Data in Review 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley