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Testing Status of Bisphenol AF 08002

 

CASRN: 1478-61-1

Formula: C15-H10-F6-O2

Synonyms/Common Names

  • 2,2-Bis(4-hydroxyphenyl)perfluoropropane
  • BPA-F
  • BP-AF
  • BPA F
  • BPAF
  • Phenol, 4,4'-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis-

Short-Term Toxicity

  • 5 days (Gavage)  (C08002)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 8, 16, 31.25, 62.5, 125, 250, 500, or 1000 mg/kg; N=4.

Modified One-Generation

  • Dose Range Finding (Dosed-Feed)  (MOG08002)  Data in Review 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 937.5, 1875, 3750, or 7500 ppm.
  • Developmental Toxicity (Dosed-Feed)  (MOG08002B)  Data in Review 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
  • F0 Generation (Dosed-Feed)  (MOG08002B)  Data in Review 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 338, 1125, or 3750 ppm.
  • Fertility Assessment (Dosed-Feed)  (MOG08002B)  Data in Review 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
  • Maternal Transfer (Dosed-Feed)  (MOG08002B)  Data in Review 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
  • 13-Week Subchronic (Dosed-Feed)  (MOG08002B)  Data in Review 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K08002)  Completed 
    • Citation: Waidyanatha S, Mathews JM, Patel PR, Black SR, Snyder RW, Fennell TR. Disposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration. Xenobiotica. 2015;45(9):811-9. doi: 10.3109/00498254.2015.1021732. Epub 2015 Jun 12.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
    • Dose: 3.4, 34, 340 mg/kg. 34 mg/kg.
  • 1 day Preliminary Toxicokinetic Study (Gavage; Intravenous)  (K08002B)  Completed 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
    • Dose: 3.4 mg/kg. 34 mg/kg. 34, 340 mg/kg.
  • Toxicokinetic Study (Gavage; Intravenous)  (K08002C)  Completed 
    • Citation: Waidyanatha S, Black SR, Aillon K, Collins B, Patel PR, Riordan F, Sutherland V, Robinson VG, Fernando R, Fennell TR. Toxicokinetics and bioavailability of bisphenol AF following oral administration in rodents: A dose, species, and sex comparison. Toxicol Appl Pharmacol. 2019 Jun 15;373:39-47. doi: 10.1016/j.taap.2019.04.015. Epub 2019 May 3.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 34 mg/kg. 34, 110 and 340 mg/kg.
  • Repeat (7 days) Toxicokinetic Study (Dosed-Feed)  (K08002D)  Completed 
    • Male Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1/N
    • Dose: 338, 1125, 3750 ppm.

Genetic Toxicology

  • 20 weeks Micronucleus (Dosed-Feed)  (G08002B)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (G08002)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 - PND 96 Developmental Immunotoxicity (Dosed-Feed)  (I08002)  On Test 
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 250, 500, or 1000 ppm.
  • Utero-Lactational (In Utero)  (R08002)  Completed 
    • Rats: Harlan Sprague-Dawley

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (C08002-02)  On Test 
    • Rats: Harlan Sprague-Dawley
  • 5 days Transcriptome Sequencing (Gavage)  (T08002)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley