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Testing Status of Vanadyl sulfate 08004

 

CASRN: 27774-13-6

Formula: O5-S-V

Synonyms/Common Names

  • Vanadium, oxo(sulfato(2-)-O)-

Short-Term Toxicity

  • 14 days (Dosed-Water)  (C08004)  Completed 
    • Citation: Harrington JM, Haines LG, Levine KE, Liyanapatirana C, Essader AS, Fernando RA, Robinson VG, Roberts GK, Stout MD, Hooth MJ, Waidyanatha S. Corrigendum to "Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water" [Toxicology and Applied Pharmacology 412 (2021) 115395]. Toxicol Appl Pharmacol. 2021 Jul 15;423:115546.https://doi.org/10.1016/j.taap.2021.115546. Epub 2021 Apr 24. Erratum for: Toxicol Appl Pharmacol. 2021 Feb 1;412:115395.
    • Citation: Harrington JM, Haines LG, Levine KE, Liyanapatirana C, Essader AS, Fernando RA, Robinson VG, Roberts GK, Stout MD, Hooth MJ, Waidyanatha S. Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water. Toxicol Appl Pharmacol. 2021 Feb 1;412:115395. https://doi.org/10.1016/j.taap.2021.115395. Epub 2021 Jan 6. Erratum in: Toxicol Appl Pharmacol. 2021 Apr 24;:115546.
    • Citation: Mutlu E, Cristy T, Graves SW, Hooth MJ, Waidyanatha S. Characterization of aqueous formulations of tetra- and pentavalent forms of vanadium in support of test article selection in toxicology studies. Environ Sci Pollut Res Int. 2017 Jan;24(1):405-416. https://doi.org/10.1007/s11356-016-7803-x. Epub 2016 Oct 10.Pubmed Abstract
    • Citation: Roberts GK, Stout MD, Sayers B, Fallacara DM, Hejtmancik MR, Waidyanatha S, Hooth MJ. 14-Day Toxicity Studies of Tetravalent and Pentavalent Vanadium Compounds in Harlan Sprague Dawley Rats and B6C3F1/N Mice via Drinking Water Exposure. Toxicol Rep. 2016;3:531-538. https://doi.org/10.1016/j.toxrep.2016.05.001. Epub 2016 May 12.
    • Citation: Roberts GK, Stout MD, Sayers B, Fallacara DM, Hejtmancik MR, Waidyanatha S, Hooth MJ. Clarification and lessons learned for reporting studies with hydrates. Citation: Roberts et al., 2016. Toxicology Reports 3: 531-538. Toxicol Rep. 2017 Dec 30;5:207-208. https://doi.org/10.1016/j.toxrep.2017.12.023.
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: Rats and mice: 0, 83.8, 167.5, 335, 670 or 1340 mg/L.
  • 90 days (Dosed-Water)  (C08004)  Data in Review 
    • Citation: Harrington JM, Haines LG, Levine KE, Liyanapatirana C, Essader AS, Fernando RA, Robinson VG, Roberts GK, Stout MD, Hooth MJ, Waidyanatha S. Corrigendum to "Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water" [Toxicology and Applied Pharmacology 412 (2021) 115395]. Toxicol Appl Pharmacol. 2021 Jul 15;423:115546.https://doi.org/10.1016/j.taap.2021.115546. Epub 2021 Apr 24. Erratum for: Toxicol Appl Pharmacol. 2021 Feb 1;412:115395.
    • Citation: Harrington JM, Haines LG, Levine KE, Liyanapatirana C, Essader AS, Fernando RA, Robinson VG, Roberts GK, Stout MD, Hooth MJ, Waidyanatha S. Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water. Toxicol Appl Pharmacol. 2021 Feb 1;412:115395. https://doi.org/10.1016/j.taap.2021.115395. Epub 2021 Jan 6. Erratum in: Toxicol Appl Pharmacol. 2021 Apr 24;:115546.
    • Citation: Mutlu E, Cristy T, Graves SW, Hooth MJ, Waidyanatha S. Characterization of aqueous formulations of tetra- and pentavalent forms of vanadium in support of test article selection in toxicology studies. Environ Sci Pollut Res Int. 2017 Jan;24(1):405-416. https://doi.org/10.1007/s11356-016-7803-x. Epub 2016 Oct 10.Pubmed Abstract
    • Citation: Roberts GK, Stout MD, Sayers B, Fallacara DM, Hejtmancik MR, Waidyanatha S, Hooth MJ. 14-Day Toxicity Studies of Tetravalent and Pentavalent Vanadium Compounds in Harlan Sprague Dawley Rats and B6C3F1/N Mice via Drinking Water Exposure. Toxicol Rep. 2016;3:531-538. https://doi.org/10.1016/j.toxrep.2016.05.001. Epub 2016 May 12.
    • Citation: Roberts GK, Stout MD, Sayers B, Fallacara DM, Hejtmancik MR, Waidyanatha S, Hooth MJ. Clarification and lessons learned for reporting studies with hydrates. Citation: Roberts et al., 2016. Toxicology Reports 3: 531-538. Toxicol Rep. 2017 Dec 30;5:207-208. https://doi.org/10.1016/j.toxrep.2017.12.023.
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: Rats and mice: 0, 21, 41.9, 83.8, 167.5, 335 ppm or mg/L.

Genetic Toxicology

  • 3 months Comet Assay (Dosed-Water)  (G08004D)  On Test 
    • Rats: Harlan Sprague-Dawley
  • 3 months Comet Assay (Dosed-Water)  (G08004E)  On Test 
    • Mice: B6C3F1
  • 3 months Micronucleus (Dosed-Water)  (G08004B)  Data in Review 
    • Rats: Harlan Sprague-Dawley
  • 3 months Micronucleus (Dosed-Water)  (G08004C)  Data in Review 
    • Mice: B6C3F1
  • Salmonella  (G08004)  Completed 
    •  Negative