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Testing Status of 2,3-Pentanedione 08010

 

CASRN: 600-14-6

Formula: C5-H8-O2

Synonyms/Common Names

  • Acetyl propionyl
  • 2,3-Pentadione

Short-Term Toxicity

  • 90 days (Inhalation)  (C08010)  Report in Preparation 
    • Citation: Morgan DL, Jokinen MP, Johnson CL, Price HC, Gwinn WM, Bousquet RW, Flake GP. Chemical reactivity and respiratory toxicity of the alpha-diketone flavoring agents: 2,3-butanedione, 2,3-pentanedione, and 2,3-hexanedione. Toxicol Pathol. 2016 Jul;44(5):763-783
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: 0, 6.25, 12.5, 25, 50, or 100; R: 20/sex/conc; M: 10/sex/conc.

Genetic Toxicology

  • Micronucleus  (G08010)  Completed 
    • Rats: Wistar Han
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G08010B)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 

Organ Systems Toxicity

  • Varies Immunotoxicity (Topical Application)  (I08010)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 1%, 2.5%, 5%, 10%, or 25%.

in vitro Testing

  • 1 day Alternate (Inhalation)  (V08010)  On Test 
    • Rats
  • 1 day Alternate (Inhalation)  (V08010B)  On Test 
    • Human (Cell Lines)