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Testing Status of Tris(4-chlorophenyl)methane 08036

 

CASRN: 27575-78-6

Synonyms/Common Names

  • TCPMe

Modified One-Generation

  • 10 days prior to mating - PND 60 Extended Dose Range Finding (Dosed-Feed)  (MOG08036)  On Test 
    • Perinatal Dose Range-Finding MOG Study of Tris(4-chlorophenyl)methane
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 10, 50, 150, or 500 ppm.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Gavage; Intravenous)  (K08036)  Completed 
    • Citation: Catlin NR, Waidyanatha S, Black SR, Mathews JM, Snyder RW, Patel PR, Watson SL, Fennell TR. Disposition of tris(4-chlorophenyl)methanol and tris(4-chlorophenyl)methane in male and female Harlan Sprague Dawley rats and B6C3F1/N mice following oral and intravenous administration. Xenobiotica. 2019 Apr;49(4):484-494. doi: https://doi.org/10.1080/00498254.2018.1463475. Epub 2018 May 3.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 1, 10, 100 mg/kg. 10 mg/kg.

Genetic Toxicology

  • 13 weeks Micronucleus (Dosed-Feed)  (G08036B)  Completed 
    • Rats: Sprague Dawley
  • 48 hours Salmonella (in-vitro)  (G08036)  Completed 
    •  Negative