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Testing Status of Pubertal Toxicity Studies 09008

 

CASRN: PUBERTALTOX

Formula: N/A

Secondary:

  • 57-63-6 - Endocrine disruptor (Ethinyl estradiol)
  • 72-43-5 - Endocrine disruptor (Methoxychlor)
  • 50471-44-8 - Endocrine disruptor (Vinclozolin)
  • 57-63-6 - Ethinyl estradiol
  • 13311-84-7 - Flutamide
  • 72-43-5 - Kid pest project (Methoxychlor)
  • 72-43-5 - Methoxychlor
  • 50-06-6 - Phenobarbital
  • 57-63-6 - Pubertal ethinyl estradiol study
  • 13311-84-7 - Pubertal flutamide study
  • 72-43-5 - Pubertal methoxychlor study
  • 50-06-6 - Pubertal phenobarbital study
  • 50471-44-8 - Pubertal vinclozolin study
  • 57-63-6 - Transgenic model evaluation (Ethinyl estradiol)
  • 50471-44-8 - Vinclozolin

Organ Systems Toxicity

  • PND range from 22 to 53/53 Continuous Breeding (Legacy) (Gavage)  (R09008)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: Vinclozolin (males): 0, 10, 30, or 100 mg/kg/day; Flutamide (males): 0, 25, or 50 mg/kg/day; Phenobarbital (males & females): 0, 25, 50, or 100 mg/kg/day; Methoxychor (females): 0, 12.5, 25, or 50 mg/kg/day; Ethinyl estradiol (females): 0, 0.0025, or 0.005 mg/kg/day; The vehicle control for both males and females was corn oil with only one control group per sex..