Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Melamine + Cyanuric Acid combination 09074

 

CASRN: MELCYANCOMB

Secondary:

  • 108-80-5 - Isocyanuric acid
  • 108-78-1 - Melamine

Short-Term Toxicity

  • 90 days (Gavage)  (C09074)  Completed 
    • Rats: F344 (NCTR)
    • Dose: Melamine: 0, 0.63, 1.25, 2.5, 5 or 10 mg/kg/bw/day followed by Cyanuric acid: 0, 0.63, 1.25, 2.5, 5 or 10 mg/kg/bw/day. Cyanuric acid gavage will be within 10 minutes after melamine gavage; 24 male/24 female dose.
  • 90 days (Gavage)  (C09074B)  Completed 
    • Rats: F344 (NCTR)
    • Dose: Melamine: 0, 0.63, 1.25, 2.5, 5.0 or 10.0 mg/kg/bw/day followed by Cynuric acid 0, 0.63, 1.25, 2.5, 5.0 or 10.0 mg/kg/bw/day. Cynuric acid gavage will be within 10 minutes after melamine gavage; 100.0 mg/kg/bw/day melamine only and 100.0 mg/kg/bw/day melamine only; 24 male / 24 female dose..
  • 90 days + recovery (Gavage)  (C09074C)  Completed 
    • Rats: F344 (NCTR)
    • Dose: 0. 1.25, 2.5, or 5.0 mg/kg.
  • 90 day (Gavage)  (C09074D)  Completed 
    • Comparison of the dose-response and temporal dynamic of traditional and novel biomarkers of nephrotoxicity upon a combined exposure to melamine and cyanuric acid in rats
    • Rats: F344 (NCTR)
    • Dose: 0. 1.25, 2.5, or 5.0 mg/kg.

Special Studies

  • Absorption Distribution Metabolism Excretion (Dosed-Feed)  (K09074)  Completed 
    • Citation: Jacob CC, Gamboa da Costa G. Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Mar 15;879(9-10):652-6. doi: 10.1016/j.jchromb.2011.01.035. Epub 2011 Feb 21.Pubmed Abstract
    • Citation: Jacob CC, Reimschuessel R, Von Tungeln LS, Olson GR, Warbritton AR, Hattan DG, Beland FA, Gamboa da Costa G. Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats. Toxicol Sci. 2011 Feb;119(2):391-7. doi: 10.1093/toxsci/kfq333. Epub 2010 Oct 28.Pubmed Abstract
    • Citation: Jacob CC, Von Tungeln LS, Vanlandingham M, Beland, FA, Gamboa da Costa G. Pharmacokinetics of melamine and cyanuric acid and their combinations in F344 rats. Toxicol Sci. 2012 Apr;126(2):317-24. doi: 10.1093/toxsci/kfr348. Epub 2012 Jan 6.Pubmed Abstract
    • Male and Female Rats: F344 (NCTR)
    • Dose: 0, 2.5, 5, 10, 15, 20, 30 mg/kg bwt/day target dose.
  • Toxicokinetic Study (Gavage; Intravenous)  (K09074C)  Completed 
    • Citation: Jacob CC, Gamboa da Costa G. Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Mar 15;879(9-10):652-6. doi: 10.1016/j.jchromb.2011.01.035. Epub 2011 Feb 21.Pubmed Abstract
    • Citation: Jacob CC, Reimschuessel R, Von Tungeln LS, Olson GR, Warbritton AR, Hattan DG, Beland FA, Gamboa da Costa G. Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats. Toxicol Sci. 2011 Feb;119(2):391-7. doi: 10.1093/toxsci/kfq333. Epub 2010 Oct 28.Pubmed Abstract
    • Citation: Jacob CC, Von Tungeln LS, Vanlandingham M, Beland, FA, Gamboa da Costa G. Pharmacokinetics of melamine and cyanuric acid and their combinations in F344 rats. Toxicol Sci. 2012 Apr;126(2):317-24. doi: 10.1093/toxsci/kfr348. Epub 2012 Jan 6.Pubmed Abstract
    • Male and Female Rats: F344 (NCTR)
    • Dose: 2 mg/kg.