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Testing Status of Glutaraldehyde 10003-W

 

CASRN: 111-30-8

Formula: C5-H8-O2

Synonyms/Common Names

  • Pentanedial (9CI)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C55425B)  Completed 
    • TOX-25 (NIH Number: 93-3348)  (Peer Review Approval 06/24/1992A )
      Toxicity Studies of Glutaraldehyde (CASRN 111-30-8) Adminstered by Inhalation to F344/N Rats and B6C3F1 Mice.
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.16, 0.5, 1.6, 5 OR 16 PPM (5/S/S).
  • 13 weeks (Inhalation)  (C55425B)  Completed 
    • TOX-25 (NIH Number: 93-3348)
      Toxicity Studies of Glutaraldehyde (CASRN 111-30-8) Adminstered by Inhalation to F344/N Rats and B6C3F1 Mice.
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 62.5, 125, 250, 500 OR 1000 PPB (10/S/S).

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C55425C)  Completed 
    • TR-490 (NIH Number: 99-3980)  (Peer Review Approval 10/30/1998A )
      Toxicology and Carcinogenesis Studies of Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 250, 500, OR 750 PPB; 50/SEX/GROUP M: 0, 62.5, 125, OR 250 PPB; 50/SEX/ GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (212368)  Completed 
    • Mice
    •  Positive 
  • Drosophila  (779687)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (887025)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (004326)  Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (146021)  Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Weakly Positive 
  • Micronucleus  (212368)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Micronucleus  (462636)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A57716)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Mouse Lymphoma  (558174)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Salmonella  (502523)  Completed 
    •  Positive 
  • Salmonella  (684635)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Equivocal 
  • Salmonella  (761374)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 

Organ Systems Toxicity

  • 5 days (mice) and 14 days (guinea pigs) Immunotoxicity (Topical Application)  (IMM87098)  Completed 
    • Female Mice: B6C3F1
    • Dose: M: 0, 0.03, 0.1, 0.3, 1.0, 3.0, OR 10%; GP: 0, 0.3, 1.0 OR 3.0% SENSITIZATION AND 10% CHALLENGE.