Testing Status of Cinnamaldehyde 10007-L

CASRN: 104-55-2

Related: TRANS-CINNAMALDEHYDE (14371-10-9)

Formula: C9-H8-O

Synonyms/Common Names

• Cinnamic aldehyde
• 3-Phenyl-2-propenal

Short-Term Toxicity

• 2 weeks (Dosed-Feed)  (C56111)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 321, 642, 1285, 2570, OR 5140 MG/KG.

Special Studies

• Absorption Distribution Metabolism Excretion (Dosed-Feed)  (S0708)  Completed 
  • Citation: Yuan J, Bucher JR, Goehl TJ, Dieter MP, Jameson CW. Quantitation of cinnamaldehyde and cinnamic acid in blood by HPLC. J Anal Toxicol. 1992 Nov-Dec;16(6):359-62.Pubmed Abstract
  • Male Rats: F344/N
• Absorption Distribution Metabolism Excretion (Gavage)  (S0710)  Completed 
  • Citation: Yuan J, Dieter MP, Bucher JR, Jameson CW. Application of microencapsulation for toxicology studies. III. Bioavailability of microencapsulated cinnamaldehyde. Fundam Appl Toxicol. 1993 Jan;20(1):83-7.Pubmed Abstract
  • Male Rats: F344/N
  • Dose: 50, 250, & 500 mg/kg.
• Toxicokinetic Study (Dosed-Feed)  (S0709)  Completed 
  • Citation: Yuan JH, Dieter MP, Bucher JR, Jameson CW. Toxicokinetics of cinnamaldehyde in F344 rats. Food Chem Toxicol. 1992 Dec;30(12):997-1004.Pubmed Abstract
  • Male and Female Rats: F344/N

Genetic Toxicology

• Micronucleus  (A60799)  Completed 
  • Mice: B6C3F1
  • Male Negative 

Organ Systems Toxicity

• 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0054A)  Completed 
  • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
  • Female Mice: Swiss
  • Dose: 1200 MG/KG BODY WEIGHT.