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Testing Status of Carbon disulfide 10014-H

 

CASRN: 75-15-0

Formula: C-S2

Synonyms/Common Names

  • Carbon bisulfide

Short-Term Toxicity

  • 13-Week (Inhalation)  (C04591B)  Completed 
    • Rats: Not Available
  • 13 weeks (Inhalation)  (C04591C)  Completed 
    • Rats: F344/N
    • Dose: RATS ONLY: 0, 50, 500, OR 800 PPM.
  • 20 weeks (Inhalation)  (C04591D)  Completed 
    • Mice: C57BL/6
    • Dose: MICE ONLY: 0, 50, 500, OR 800 PPM.

Special Studies

  • Absorption Disposition Metabolism Elimination (Intravenous)  (K00284)  Completed 
    • Rats
  • Toxicokinetic Study (Inhalation; Intravenous)  (S0559)  Completed 
    • Citation: Moorman MP, Sills RC, Collins BJ, Morgan DL. Carbon disulfide neurotoxicity in rats: II. Toxicokinetics. Neurotoxicology. 1998 Feb;19(1):89-97.Pubmed Abstract
    • Male Rats: F344/N; Female Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (635693)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (105153)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (436781)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment (Inhalation)  (NTA94007)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male Rats: F344/N
  • 0 to 21 GD, or 7 to 21 GD, or 7 hour/day, 5 day/week for 3 weeks plus 0 to 21 GD or 7 hour/day, 5 days/week for 3 weeks plus 7 to 21 GD Conventional Teratology (Inhalation)  (T0023A)  Completed 
    • Citation: Teratogenic-Mutagenic Risk of Workplace Contaminants: Trichloroethylene, Perchloroethylene, Carbon Disulfide
    • Female Rabbit: New Zealand White
    • Dose: 20, 40 ppm 7 hr/day.
  • 0 to 18 GD, or 6 to 18 GD, or 7 hour/day 5 day/week for 3 weeks plus 0 to 18 GD, or 7 hour/day 5 day/week for 3 weeks plus 6 to 18 GD Conventional Teratology (Inhalation)  (T0023B)  Completed 
    • Citation: Teratogenic-Mutagenic Risk of Workplace Contaminants: Trichloroethylene, Perchloroethylene, Carbon Disulfide
    • Female Rats: Sprague Dawley
    • Dose: 20, 40 ppm 7 hr/day.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER84053)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 100, 200, 400, 600 MG/KG/DAY.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER84054)  Completed 
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: 0, 25, 75, 150 MG/KG/DAY.