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Testing Status of Ethylene oxide 10020-A

 

CASRN: 75-21-8

Formula: C2-H4-O

Synonyms/Common Names

  • Oxirane (9CI)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C50088)  Completed 
    • Mice: B6C3F1
  • 13-Week (Inhalation)  (C50088)  Completed 
    • Mice: B6C3F1
    • Dose: 0, 50, 100, 200, 400, 600 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C50088)  Completed 
    • TR-326 (NIH Number: 88-2582)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Ethylene Oxide (CASRN 75-21-8) in B6C3F1 Mice (Inhalation Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: 0, 50, 100 PPM/50 PER GROUP.

Organ Systems Toxicity

  • Biochemical Specific Locus (Inhalation)  (BSLM38)  Completed 
    • Citation: Lewis, S.E., Barnett, L.B., Felton, C., Johnson, F.M., Skow, L.C., Cacheiro, N., and Shelby, M.D. Dominant visible and electrophoretically expressed mutations induced in male mice exposed to ethylene oxide by inhalation. Environ. Mutagen. 8:867-872 (1986).
    • Male Mice: DBA/2J
    • Mice Male Positive 
  • 5 consecutive days Continuous Breeding (Legacy) (Inhalation)  (T0024C)  Completed 
    • Male Mice: C3H
    • Dose: 100 ppm 7 hr/day for 5 days.
  • 4 to 6 GD, 6 to 8 GD, 8 to 10 GD, 10 to 12 GD Conventional Teratology (Intravenous)  (T0024A)  Completed 
    • Citation: Teratologic Evaluation of Ethylene Oxide
    • Female Mice: Swiss
    • Dose: 75, 150 mg/kg/day.
  • 8 to 16 GD or 1 to 16 GD or 3 weeks before breeding plus 1 to 16 GD Conventional Teratology (Inhalation)  (T0024D)  Completed 
    • Citation: Teratogenic Study of Ethylene and Propylene Oxide and n-Butyl Acetate
    • Female Rats: Sprague Dawley
    • Dose: 150 ppm 7 hr/day.
  • 7 to 19 GD or 1 to 19 GD Conventional Teratology (Inhalation)  (T0024E)  Completed 
    • Citation: Teratogenic Study of Ethylene and Propylene Oxide and n-Butyl Acetate
    • Female Rabbits: New Zealand White
    • Dose: 150 ppm 7 hr/day.
  • 6 to 14 GD and 6 to 9 GD Conventional Teratology (Intravenous)  (TER82078)  Completed 
    • Female Rabbits: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: PART A: GD 6-14, WATER VEHICLE AT 0, 9, 18, & 36 MG/KG. PART B: GD 6-9, 5% DEXTROSE VEHICLE AT 0, 18, & 36 MG/KG..
  • Dominant Lethal (Female) (Dosed-Feed)  (DLF023)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L. Concentration-response curves for ethylene oxide-induced heritable translocations and dominant lethal mutations. Environ. Mol. Mutagen. 16:126-131 (1990).
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
  • Dominant Lethal (Male)  (DLM022)  Completed 
    • Citation: Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Braden, P.W. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutation Res. 176:269-274 (1987).
    • Male Mice: C3H X 101
    • Mice Male Positive 
  • Heritable Translocation Test (Dosed-Feed)  (HTM32)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L. Concentration-response curves for ethylene oxide-induced heritable translocations and dominant lethal mutations. Environ. Mol. Mutagen. 16:126-131 (1990).
    • Male Mice: C3H X 101
    • Mice Male Positive 
  • Morphological Specific Locus (Dosed-Feed)  (MSLM42)  Completed 
    • Citation: Russell, L.B., Cummings, R.B., and Hunsicker, P.R. Specific-Locus mutation rates in the mouse following inhalation of ethylene oxide and application of the results estimation of human genetic risk. Mutation Res. 129:381-388 (1984).
    • Male Mice: 101 X C3H
    • Mice Male Negative 
  • Preimplantation Zygote Effects (Dosed-Feed)  (PZEF48)  Completed 
    • Citation: Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Braden, P.W. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutation Res. 176:269-274 (1987).
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
  • Total Reproductive Capacity (Gavage)  (TRC98017)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Positive