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Testing Status of Hydroquinone 10022-H

 

CASRN: 123-31-9

Formula: C6-H6-O2

Synonyms/Common Names

  • 1,4-Benzenediol (9CI)

Short-Term Toxicity

  • 13-Week (Gavage)  (C55834B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 25, 400 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55834B)  Completed 
    • TR-366 (NIH Number: 89-2821)  (Peer Review Approval 10/03/1988A )
      Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 25, 50, M: 0, 50, 100 MG/KG/65 PER GROUP.

Modified One-Generation

  • Dose Range Finding Selected (MOG10022)  
    • Rats: Harlan Sprague-Dawley
  • Developmental Toxicity (Gavage) Selected (MOG10022B)  
    • Rats: Harlan Sprague-Dawley
  • F0 Generation (Gavage) Selected (MOG10022B)  
    • Rats: Harlan Sprague-Dawley
  • Fertility Assessment (Gavage) Selected (MOG10022B)  
    • Rats: Harlan Sprague-Dawley
  • Neurotoxicology Assessment (Gavage) Selected (MOG10022B)  
    • Rats: Harlan Sprague-Dawley

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (K10022)  Completed 
    • Citation: Black SR, Fennell TR, Mathews JM, Snyder RW, Patel PR, Watson SL, Sutherland V, Waidyanatha S. Disposition of [14C]hydroquinone in Harlan Sprague-Dawley rats and B6C3F1/N mice: species and route comparison. Xenobiotica. 2018 Nov;48(11):1128-1141. doi: 10.1080/00498254.2017.1398847. Epub 2017 Nov 22.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 0.5, 5, or 50 mg/kg. 2, 10 or 20%. 5 mg/kg.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (886668)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (814626)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Mouse Lymphoma  (327913)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Micronucleus  (A06686)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (296791)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative