Testing Status of 8-Methoxypsoralen 10023-L

CASRN: 298-81-7

Formula: C12-H8-O4

Synonyms/Common Names

• 9-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one
• 8-MOP

Short-Term Toxicity

• 14-Day (Gavage)  (C55903)  Completed 
  • Rats: F344/N
• 13-Week (Gavage)  (C55903)  Completed 
  • Rats: F344/N
  • Dose: 0, 25, 400 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

• 2 years (Gavage)  (C55903)  Completed 
  • TR-359 (NIH Number: 89-2814)  (Peer Review Approval 04/18/1988A )
    Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
  • Carcinogenesis Results
    • Male Rats Clear Evidence 
    • Female Rats No Evidence 
  • Dose: R: 0, 37.5, 75 MG/KG/50 PER GROUP.

Genetic Toxicology

• Chromosome Aberrations  (501444)  Completed 
  • Mice
  •  Positive 
• In Vitro Cytogenetics (CA/SCE)  (421568)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Positive 
• Micronucleus  (158726)  Completed 
  • Mice: B6C3F1
  • Male Equivocal 
• Salmonella  (773087)  Completed 
  •  Positive 

Organ Systems Toxicity

• 6 to 9 GD Conventional Teratology (Gavage)  (TER91016)  Completed 
  • Female Rabbits: New Zealand White
  • Rabbits Maternal Positive 
  • Rabbits Fetal Negative 
  • Dose: 0, 40, 80, 105 MG/KG.
• 6 to 16 GD Conventional Teratology (Gavage)  (TER91017)  Completed 
  • Rats: Sprague Dawley
  • Rats Maternal Positive 
  • Rats Fetal Positive 
  • Dose: 0, 20, 80, 120, 160 MG/KG/DAY.
• 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90007)  Completed 
  • Female Rats: Sprague Dawley
  • Dose: 0, 20, 100, 200, 400, 600 MG/KG.
• 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP90008)  Completed 
  • Female Rabbits: New Zealand White
  • Dose: 0, 10, 50, 80, 160 MG/KG.
• 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP91017)  Completed 
  • Female Rabbits: New Zealand White
  • Dose: 0, 10, 50, 80, 105 MG/KG.