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Testing Status of Bis(2-ethylhexyl) tetrabromophthalate 10033

 

CASRN: 26040-51-7

Formula: C24-H34-Br4-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, 3,4,5,6-tetrabromo-, 1,2-bis(2- ethylhexyl) ester
  • Flame Retardant 2
  • TBPH

Short-Term Toxicity

  • 5 days (Gavage)  (C10333)  Report in Preparation 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.

Organ Systems Toxicity

  • Utero-Lactational  (R10333)  Completed 

    Toxicogenomics

    • 5 days Microarray Analysis (Gavage)  (T10333)  Report in Preparation 
      • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat. Toxicol Lett. 2020 Oct 10;332:222-234. doi: 10.1016/j.toxlet.2020.07.016. Epub 2020 Jul 15.Pubmed Abstract
      • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data Brief. 2020 Aug 5;32:106136. doi: https://doi.org/10.1016/j.dib.2020.106136.Pubmed Abstract
      • Rats: Hsd:Sprague Dawley SD
      • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.