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Testing Status of Boric acid 10035-D

 

CASRN: 10043-35-3

Formula: B-H3-O3

Synonyms/Common Names

  • Boracic acid

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C56417)  Completed 
    • Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C56417)  Completed 
    • Mice: B6C3F1
    • Dose: 0, 1200, 2000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C56417)  Completed 
    • TR-324 (NIH Number: 88-2580)  (Peer Review Approval 03/26/1986A )
      Toxicology and Carcinogenesis Studies of Boric Acid (CASRN 10043-35-3) in B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 2500, 5000 PPM/50 PER GROUP.

Modified One-Generation

  • GD 6 - PND 28 Dose Range Finding (Gavage)  (MOG10035)  On Test 
    • Rats: Harlan Sprague-Dawley
  • F0 Generation (Gavage)  (MOG10035B)   
    • Rats: Harlan Sprague-Dawley

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0787)  Completed 
    • Citation: Ku WW, Chapin RE, Moseman RF, Brink RE, Pierce KD, Adams KY. Tissue disposition of boron in male Fischer rats. Toxicol Appl Pharmacol. 1991 Oct;111(1):145-51.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0, 9000 ppm (w/w) boric acid (1575 ppm boron).
  • Mechanisms (Dosed-Feed)  (S0788)  Completed 
    • Citation: Ku WW, Chapin RE, Wine RN, Gladen BC. Testicular toxicity of boric acid (BA): relationship of dose to lesion development and recovery in the F344 rat. Reprod Toxicol. 1993 Jul-Aug;7(4):305-19.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0, 3000, 4500, 6000, 9000 ppm.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (153962)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (621739)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Salmonella  (683471)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (789471)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Equivocal 

Organ Systems Toxicity

  • 27 weeks Continuous Breeding (Legacy) (Dosed-Feed)  (RACB88034)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, 1000, 4500, 9000 PPM; 0, 4500 PPM; 0, 1000 PPM.
  • 10, 14, or 21 days Spermiation Inhibition (Dosed-Feed)  (RACB93162)  Completed 
    • Male Rats: F344/N
    • Dose: 0, ≤ 9000 PPM.
  • 0 to 20 GD Conventional Teratology (Dosed-Feed)  (TER89027)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, .1, .2, .4, .8%.
  • 1 to 17 GD Conventional Teratology (Dosed-Feed)  (TER89028)  Completed 
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 0.1, 0.2, 0.4%.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER90003)  Completed 
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: 0, 62.5, 125, 250 MG/KG/DAY.
  • 14 to 17 GD Conventional Teratology (Dosed-Feed)  (TER90123)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 0.8, 1.6, 2.4% AND PAIR FED CONTROL FOR 2.4%.
  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER93138)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, .4, .5, .6, .8% *.