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Testing Status of Caffeine 10036-G

 

CASRN: 58-08-2

Formula: C8-H10-N4-O2

Synonyms/Common Names

  • 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C02733)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Water)  (C02733)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 188, 3000, M: 0, 94, 1500 PPM/12 PER GROUP.

Special Studies

  • C. elegans  (S0873)  Completed 
    • C. elegans
    • Dose: feed (0, .5, .79, 1.3, 2, 3.2, 5, 7.9, 13, 20, 32, 50) mM 03/23/05 repro (0, .25, .4, .63, 1, 1.6, 2.5, 4, 6.3, 10, 16, 25) mM 03/23/05growth (0, .25, .4, .63, 1, 1.6, 2.5, 3, 6.3, 10, 16, 25) mM 10/09/05.

Genetic Toxicology

  • Salmonella  (075951)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (N-9342)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB81078)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, .012, .033, .1, .3, 1.0%; 0, .012, .025, .05%; N/A; 0, .05%.
  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84044)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, .01, .03, .1, .3, 1.0%; 0, .012, .025, .05%; 0, .05%; N/A.
  • 14 weeks Continuous Breeding (Legacy) (Gavage)  (RACB94006)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: TASK 1: 0, 50, 100, 150, OR 200 MG/KG; TASK 2: 0, 12.5, 25, OR 50 MG/KG; TASK 3: 0 OR 50 MG/KG; TASK 4: 0, 12.5, 25, OR 50 MG/KG.
  • 11 GD Conventional Teratology (Intravenous)  (T0009A)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 37.5, 75, 112.5, 150 MG/KG/DAY.
  • 0 to 19 GD Conventional Teratology (Gavage)  (T0009D)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 40, 80 MG/KG/DAY.