Testing Status of Diphenhydramine hydrochloride 10040-R
CASRN: 147-24-0
Formula: C17-H21-N-O.Cl-H
Synonyms/Common Names
- BAX
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C56075)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C56075)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 156, OR 2500 M: 0, 78, OR 1250 PPM; 10/GROUP.
Long-Term Carcinogenicity
- 113 weeks (Dosed-Feed)
(C56075)
Completed
- TR-355 (NIH Number: 89-2810)
(Peer Review Approval 10/03/1988A )
Toxicology and Carcinogenesis Studies of Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats Equivocal Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: MR: 0, 313, OR 625 FR&M: 0, 156, OR 313 PPM; 50/GROUP.
- TR-355 (NIH Number: 89-2810)
(Peer Review Approval 10/03/1988A )
- 2 years (Dosed-Feed)
(C56075)
Completed
- TR-355 (NIH Number: 89-2810)
(Peer Review Approval 10/03/1988A )
Toxicology and Carcinogenesis Studies of Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats Equivocal Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: MR: 0, 313, OR 625 FR&M: 0, 156, OR 313 PPM; 50/GROUP.
- TR-355 (NIH Number: 89-2810)
(Peer Review Approval 10/03/1988A )
Special Studies
- Absorption Disposition Metabolism Elimination (Dosed-Feed)
(S0099)
Completed
- Male Rats: F344/N
- Dose: 313, 625 PPM FOR 30 DAYS.
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(195192)
Completed
- Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Positive
- Mouse Lymphoma
(590709)
Completed
- Mice
- Negative
- Salmonella
(637175)
Completed
- Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
- Negative
- She Cell Transformation
(A81866)
Completed
- SHE Cell Transformation Negative
Organ Systems Toxicity
- 6 to 15 GD Conventional Teratology (Gavage)
(TER82067)
Completed
- Female Rats: Sprague Dawley
- Rats Maternal Positive
- Rats Fetal Positive
- Dose: 25, 50, 100 MG/KG/DAY.
- 11 to 14 GD Conventional Teratology (Gavage)
(TER82068)
Completed
- Female Mice: Swiss
- Mice Maternal Positive
- Mice Fetal Positive
- Dose: 80, 160, 200 MG/KG/DAY.
- 6 to 15 GD Conventional Teratology (Gavage)
(TER82069)
Completed
- Female Mice: Swiss
- Mice Maternal Positive
- Mice Fetal Positive
- Dose: 40, 80, 160 MG/KG/DAY.