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Testing Status of Nitrofurazone 10047-T

 

CASRN: 59-87-0

Formula: C6-H6-N4-O4

Synonyms/Common Names

  • 2((5-Nitro-2-furanyl)methylene)hydrazinecarboxamide

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C56064)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 7 weeks (Dosed-Feed)  (C95005)  Completed 
    • Mice: B6C3F1
    • Dose: FEMALE MICE ONLY: 0 OR 310 PPM.
  • 13-Week (Dosed-Feed)  (C56064)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 20 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C56064)  Completed 
    • TR-337 (NIH Number: 88-2593)  (Peer Review Approval 07/14/1987A )
      Toxicology and Carcinogenesis Studies of Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 310, 620, M: 0, 150, 310 PPM/50 PER GROUP.
  • 2 years (Dosed-Feed)  (C95005)  Completed 
    • Mice: B6C3F1
    • Dose: FEMALE MICE ONLY: 0 OR 310 PPM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (356548)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A59017)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (267199)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Salmonella  (364720)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 

Organ Systems Toxicity

  • 27 weeks Continuous Breeding (Legacy) (Dosed-Feed)  (RACB89020)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, 100, 200, 400, 600, 900 PPM; 0, 100, 375, 750 PPM; 0, 750 PPM; 0, 100, 375 PPM.
  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER85092)  Completed 
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 0.0038, 0.0075, 0.025, 0.050%.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER87093)  Completed 
    • Female Rabbits: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: 0, 5, 10, 15, 20 MG/KG/DAY.
  • Immunotoxicity (Gavage)  (IMM90011)  Completed 
    • Female Mice: B6C3F1
    • Mice Female Negative 
    • Dose: 0, 40, 60, 80 MG/KG.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0012A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 100 MG/KG BODY WT.