Testing Status of Benzofuran 10058-F

CASRN: 271-89-6

Formula: C8-H6-O

Synonyms/Common Names

• Coumarone

Short-Term Toxicity

• 14-Day (Gavage)  (C56166)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C56166)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 31.25, 500 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

• 2 years (Gavage)  (C56166)  Completed 
  • TR-370 (NIH Number: 89-2825)  (Peer Review Approval 03/13/1989A )
    Toxicology and Carcinogenesis Studies of Benzofuran (CASRN 271-89-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats No Evidence 
    • Female Rats Some Evidence 
    • Male Mice Clear Evidence 
    • Female Mice Clear Evidence 
  • Dose: FR&MM: 0, 60, 120, MR: 0, 30, 60, FM: 0, 120, 240 MG/KG/50 PER GROUP.

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (622347)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Negative 
• Mouse Lymphoma  (158938)  Completed 
  • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
  • Mice
  •  Positive 
• Salmonella  (524374)  Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative