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Testing Status of Chlorinated paraffins: C23, 43% chlorine 10062-P

 

CASRN: 108171-27-3

Formula: C24-H43-Cl7

Synonyms/Common Names

  • Cereclor 42
  • Chlorowax 40

Short-Term Toxicity

  • 14-Day (Gavage)  (C53543)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C53543)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 250, or 3750 M: 0, 469, or 7500 mg/kg/10 per group.

Long-Term Carcinogenicity

  • 109 weeks (Gavage)  (C53543)  Completed 
    • TR-305 (NIH Number: 86-2561)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: FR: 0, 100, 300, or 900, MR: 0, 1875, or 3750, M: 0, 2500, or 5000 mg/kg/50 per group.
  • 2 years (Gavage)  (C53543)  Completed 
    • TR-305 (NIH Number: 86-2561)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: FR: 0, 100, 300, or 900, MR: 0, 1875, or 3750, M: 0, 2500, or 5000 mg/kg/50 per group.

Genetic Toxicology

  • Mouse Lymphoma  (010900)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Negative 
  • Salmonella  (104775)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative