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Testing Status of 2-Mercaptobenzothiazole 10073-C

 

CASRN: 149-30-4

Formula: C7-H5-N-S2

Synonyms/Common Names

  • 2(3H)-Benzothiazolethione (9Ci)
  • MBT

Short-Term Toxicity

  • 14-Day (Gavage)  (C56519)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56519)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, .1, 10 MG/M3/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56519)  Completed 
    • TR-332 (NIH Number: 88-2588)  (Peer Review Approval 03/04/1987A )
      Toxicology and Carcinogenesis Studies of 2-Mercaptobenzothiazole (CASRN 149-30-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: FR: 0, 188, 375, MR&M: 0, 375, 750 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (748636)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Not a Valid Test 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (997320)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Not Tested 
  • Micronucleus  (A38881)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A62048)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (920542)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Salmonella  (855075)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Equivocal 
  • Salmonella  (876400)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM90003)  Completed 
    • Female Mice: B6C3F1
    • Mice Female Positive 
    • Dose: 0, 1, 3, 7.5%.