Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Chlordecone 10097-H

 

CASRN: 143-50-0

Formula: C10-Cl10-O

Synonyms/Common Names

  • 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
  • Kepone

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00191)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00191)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00191)  Completed 
    • TR-000 (143-50-0) (NIH Number: 76-1278)  (Peer Review Approval NA)
      Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CASRN 143-50-0)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: FR: 0, 18, 26 (AVG), MR: 0, 8, 24 (AVG), FM: 0, 20, 40 (AVG), MM: 0, 20, 23 (AVG) PPM.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0447)  Completed 
    • Citation: Bungay PM, Dedrick RL, Matthews HB. Enteric transport of chlordecone (Kepone) in the rat. J Pharmacokinet Biopharm. 1981 Jun;9(3):309-41.Pubmed Abstract
    • Rats: Sprague Dawley
  • C. elegans  (W10097)  Completed 
    • C. elegans
    • Dose: 100, 75, 50 uM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (232320)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (163075)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (663576)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (795821)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment (Gavage & Intraperitoneal Injection)  (NTA94020)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats: F344/N