Testing Status of cis-Dichlorodiamine platinum 10108-W
CASRN: 15663-27-1
Formula: Cl2-H6-N2-Pt
Synonyms/Common Names
- Cisplatin
- cis-Platinum
- Diamminedichloroplatinum
- Platinol
- Platinum diamminodichloride
Genetic Toxicology
- Drosophila
(059070)
Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
- Sex-Linked Recessive Lethal Positive
- Reciprocal Translocation Positive
- In Vitro Cytogenetics (CA/SCE)
(593235)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Salmonella
(839608)
Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Positive
Organ Systems Toxicity
- Continuous Breeding (Legacy) (Gavage)
(RACB94020)
Completed
- Male Rats: CD-1
- Dominant Lethal (Female) (Gavage)
(DLF061)
Completed
- Citation: Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Bishop, J.B., and Generoso, W.M. Female-specific dominant lethal effects in mice. Mutation Res. 230:230 (1990).
- Female Mice: C3H X C57BL
- Mice Female Positive
- Dominant Lethal (Female) (Dosed-Feed)
(DLF062)
Completed
- Citation: Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Bishop, J.B., and Generoso, W.M. Female-specific dominant lethal effects in mice. Mutation Res. 230:230 (1990).
- Female Mice: SEC X C57BL
- Mice Female Positive
- Dominant Lethal (Male) (Dosed-Feed)
(DLM060)
Completed
- Citation: Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Bishop, J.B., and Generoso, W.M. Female-specific dominant lethal effects in mice. Mutation Res. 230:230 (1990).
- Male Mice: C3H X 101
- Mice Male Negative
- single exposure Dominant Lethal (Intraperitoneal Injection)
(TER94004)
Completed
- Male Rats: Sprague Dawley
- Dose: 0, 6, 8, 10, 12 MG/KG IN DRF STUDY; 0 & 8 MG/KG DL STUDY.
- Total Reproductive Capacity (Gavage)
(TRC98027)
Completed
- Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
- Female Mice: B6C3F1/N
- Mice Female Positive