Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Dimethoxane 10114-N

 

CASRN: 828-00-2

Formula: C8-H14-O4

Synonyms/Common Names

  • 2,6-Dimethyl-1,3-dioxan-4-ol acetate

Short-Term Toxicity

  • 14-Day (Gavage)  (C56213)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56213)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 31.5, 500 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56213)  Completed 
    • TR-354 (NIH Number: 89-2809)  (Peer Review Approval 10/03/1988A )
      Toxicology and Carcinogenesis Studies of Dimethoxane (CASRN 828-00-2) (Commercial Grade) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: MR: 0, 62.5, 125, FR: 0, 125, 250, M: 0, 250, 500 MG/KG/60 PER GROUP.

Genetic Toxicology

  • Drosophila  (194110)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Positive 
  • In Vitro Cytogenetics (CA/SCE)  (028235)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (742172)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive