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Testing Status of Ethylene glycol 10118-E

 

CASRN: 107-21-1

Formula: C2-H6-O2

Synonyms/Common Names

  • 1,2-Ethanediol

Short-Term Toxicity

  • 13-Week (Dosed-Feed)  (C00920A)  Completed 
    • Mice: B6C3F1
    • Dose: R&M: 0, .32, 5 %/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C00920A)  Completed 
    • TR-413 (NIH Number: 93-3144)  (Peer Review Approval 07/09/1991A )
      Toxicology and Carcinogenesis Studies of Ethylene Glycol (CASRN 107-21-1) in B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: MM: 0, .625, 1.25, 2.5%, FM: 0, 1.25, 2.5, 5.0%/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (706666)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (062928)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Negative 
  • Salmonella  (195794)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84051)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .25, .5, 1%; N/A; N/A.
  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84096)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .5, 1.0, 1.5%; N/A; N/A.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0061A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 11090 MG(10ML UNDILUTED)/KG BD WT.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER84073)  Completed 
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 750, 1500, 3000 MG/KG/DAY.
  • 6 to 20 GD Conventional Teratology (Gavage)  (TER84128)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Negative 
    • Rats Fetal Positive 
    • Dose: 250, 1250, 2250 MG/KG/DAY.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER89126)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 2500 MG/KG.
  • Conventional Teratology (Gavage)  (TER90005)  Completed 
    • Rabbit: New Zealand White
    • Rabbits Maternal Negative 
    • Rabbits Fetal Negative 
    • Dose: 100, 500, 1000, 2000 MG/KG.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER90072)  Completed 
    • Citation: Final Report: Teratologic Evaluation of Ethylene Glycol Administered to CD Rats on Gestational Days 6 through 15.
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 1250, 2500, 5000 MG/KG/DAY.