Testing Status of Furfuryl alcohol 10121-J

CASRN: 98-00-0

Formula: C5-H6-O2

Synonyms/Common Names

• 2-Furanmethanol (9CI)
• Furylcarbinol
• 2-Hydroxymethylfuran

Short-Term Toxicity

• 2 weeks (Inhalation)  (C56224B)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0, 16, 31, 63, 125 AND 250 PPM (5/S/S).
• 13 weeks (Inhalation)  (C56224B)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0, 2, 4, 8, 16 OR 32 PPM / (10/S/S).

Long-Term Carcinogenicity

• 2 years (Inhalation)  (C56224C)  Completed 
  • TR-482 (NIH Number: 99-3972)  (Peer Review Approval 12/10/1997A )
    Toxicology and Carcinogenesis Studies of Furfural Alcohol in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Some Evidence 
    • Female Rats Equivocal Evidence 
    • Male Mice Some Evidence 
    • Female Mice No Evidence 
  • Dose: R&M: 0, 2, 8, OR 32 PPM (50/SEX/SPECIES/GROUP).

Special Studies

• Absorption Distribution Metabolism Excretion (Gavage)  (S0094)  Completed 
  • Citation: Nomeir AA, Silveira DM, McComish MF, Chadwick M. Comparative metabolism and disposition of furfural and furfuryl alcohol in rats. Drug Metab Dispos. 1992 Mar-Apr;20(2):198-204.Pubmed Abstract
  • Male Rats: F344/N

Genetic Toxicology

• Chromosome Aberrations  (150910)  Completed 
  • Mice
  •  Negative 
• In Vitro Cytogenetics (CA/SCE)  (799233)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Equivocal 
• Micronucleus  (A08423)  Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (709717)  Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Sister Chromatid Exchanges  (150910)  Completed 
  • Mice
  • Sister Chromatid  Negative