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Testing Status of Mercuric chloride 10133-A

 

CASRN: 7487-94-7

Formula: Cl2-Hg

Synonyms/Common Names

  • Mercury chloride (HgCl2) (9CI)

Short-Term Toxicity

  • 14-Day (Gavage)  (C60173)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C60173)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, .312, 5.0, M: 0, 1.25, 20.0 MG/KG/40 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C60173)  Completed 
    • TR-408 (NIH Number: 93-3139)  (Peer Review Approval 07/10/1991A )
      Toxicology and Carcinogenesis Studies of Mercuric Chloride in F344 Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 2.5, 5, M: 0, 5, 10 MG/KG/60 PER GROUP.

Special Studies

  • C. elegans  (S0954)  Completed 
    • C. elegans

Genetic Toxicology

  • Drosophila  (515345)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (700546)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (289120)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (862036)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative