Testing Status of 5,5-Diphenylhydantoin (phenytoin) 10156-D
CASRN: 57-41-0
Formula: C15-H12-N2-O2
Synonyms/Common Names
- 2,4-Imidazolidinedione, 5,5-diphenyl-
- Phenytoin
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C55765)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C55765)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 300, 4800, M: 0, 75, 1200 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C55765)
Completed
- TR-404 (NIH Number: 94-2859)
(Peer Review Approval 06/24/1992A )
Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (Phenytoin) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice Clear Evidence
- Dose: R: 0, 240, 800, 2400, MM: 0, 30, 100, 300, FM: 0, 60, 200, 600 PPM/50 PER GROUP.
- TR-404 (NIH Number: 94-2859)
(Peer Review Approval 06/24/1992A )
Special Studies
- Absorption Disposition Metabolism Elimination (Dosed-Feed)
(S0450)
Completed
- Citation: Colburn WA, Matthews HB. Pharmacokinetics in the interpretation of chronic toxicity tests: the last-in, first-out phenomenon. Toxicol Appl Pharmacol. 1979 May;48(3):387-95.Pubmed Abstract
- Male Rats: Sprague Dawley
- C. elegans
(S0923)
Completed
- C. elegans
- Dose: Feed ( 0, .05, .063, .79, .1, .13, .16, .2, .25. .32. .4, .5 mM) 6/27/06 Repro (0, .025, .032, .04, .05, .063, .079, .1, .13, .16, .20, .25 mM) 6/18/06 Growth (0, .025, .032, .04, .05, .063, .079, .1, .13, .16, .20, .25 mM).
Genetic Toxicology
- Chromosome Aberrations
(252423)
Completed
- Mice
- Negative
- Drosophila
(486572)
Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(335957)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Micronucleus
(110489)
Completed
- Mice: BALB/c
- Male Negative
- Micronucleus
(252424)
Completed
- Mice: B6C3F1
- Male Negative
- Female NA
- Mouse Lymphoma
(404495)
Completed
- Mice
- Negative
- Salmonella
(255790)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Negative
- Salmonella
(599479)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Negative
- Sister Chromatid Exchanges
(252423)
Completed
- Mice
- Sister Chromatid Equivocal