Testing Status of 1,2,3-Trichloropropane 10186-C
CASRN: 96-18-4
Formula: C3-H5-Cl3
Synonyms/Common Names
- Allyl trichloride
Short-Term Toxicity
- 13-Week (Gavage)
(C60220A)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 8, 250 MG/KG/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C60220B)
Completed
- TR-384 (NIH Number: 94-2839)
(Peer Review Approval 07/09/1991A )
Toxicology and Carcinogenesis Studies of 1,2,3-Trichloropropane in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: R: 0, 3, 10, 30, M: 0, 6, 20, 60 MG/KG.
- TR-384 (NIH Number: 94-2839)
(Peer Review Approval 07/09/1991A )
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage; Intravenous)
(S0670)
Completed
- Male Rats: Fischer 344
- Dose: 0.35, 3.0, and 32 mg/kg. 3.6 mg/kg.
- Absorption Distribution Metabolism Excretion (Intraperitoneal Injection)
(S0671)
Completed
- Male Rats: F344/N
- Dose: 30 mg/kg.
- Absorption Distribution Metabolism Excretion (Intraperitoneal Injection; Intravenous)
(S0705)
Completed
- Citation: Volp RF, Sipes IG, Falcoz C, Carter DE, Gross JF. Disposition of 1,2,3-trichloropropane in the Fischer 344 rat: conventional and physiological pharmacokinetics. Toxicol Appl Pharmacol. 1984 Aug;75(1):8-17.Pubmed Abstract
- Male Rats: Fischer 344
- Dose: 3.6 mg/kg. 50 mg/kg.
- Absorption Distribution Metabolism Excretion (Gavage)
(S0706)
Completed
- Citation: Mahmood NA, Overstreet D, Burka LT. Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice. Drug Metab Dispos. 1991 Mar-Apr;19(2):411-8.Pubmed Abstract
- Male and Female Rats: F344/N; Male Mice: B6C3F1
- Dose: 30 and 60 mg/kg. 30 mg/kg.
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(539595)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Mouse Lymphoma
(544452)
Completed
- Mice
- Positive
- Salmonella
(137369)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
- Salmonella
(600157)
Completed
- Positive
Organ Systems Toxicity
- greater than 120 days Continuous Breeding (Legacy) (Gavage)
(RACB91039)
Completed
- Male and Female Mice: Swiss
- Dose: 0, 12.5, 25, 50, 100, 200 MG/KG; 0, 30, 60, 120 MG/KG/DAY; 0, 120 MG/KG; 0, 30, 60, 120 MG/KG.