Testing Status of p-Nitroaniline 10217-F
CASRN: 100-01-6
Formula: C6-H6-N2-O2
Synonyms/Common Names
- 4-Nitrobenzeneamine (9CI)
Short-Term Toxicity
- 2 weeks (Gavage)
(C60786A)
Completed
- Mice: B6C3F1
- 13 weeks (Gavage)
(C60786A)
Completed
- Mice: B6C3F1
- Dose: 0, 1, 100 MG/10ML/KG/40 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C60786B)
Completed
- TR-418 (NIH Number: 93-3149)
(Peer Review Approval 11/21/1991A )
Toxicology and Carcinogenesis Studies of p-Nitroaniline in B6C3F1 Mice (Gavage Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Mice Equivocal Evidence
- Female Mice No Evidence
- Dose: 0, 3, 30, 100 MG/KG/50 PER GROUP.
- TR-418 (NIH Number: 93-3149)
(Peer Review Approval 11/21/1991A )
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage; Intravenous)
(S0025)
Completed
- Citation: Chopade HM, Matthews HB. Disposition and metabolism of p-nitroaniline in the male F-344 rat. Fundam Appl Toxicol. 1984 Jun;4(3 Pt 1):485-93.Pubmed Abstract
- Male Rats: Fischer 344
- Dose: 10 micromol/kg. 2, 100 micromol/kg.
Genetic Toxicology
- Drosophila
(344224)
Completed
- Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Drosophila
(396966)
Completed
- Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(491256)
Completed
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Positive
- In Vitro Cytogenetics (CA/SCE)
(786885)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Mouse Lymphoma
(368298)
Completed
- Mice
- Positive
- Salmonella
(074958)
Completed
- Positive
- Salmonella
(615042)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
Organ Systems Toxicity
- 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)
(T0046)
Completed
- Citation: Screening of Priority Chemicals for Reproductive Hazards
- Female Mice: Swiss
- Dose: 1200 MG/KG BD WT.