Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Riddelliine 10237-W


CASRN: 23246-96-0

Formula: C18-H23-N-O6

Synonyms/Common Names

  • Riddelline
  • Senecionan-11,16-dione, 13,19-didehydro-12,18-dihydroxy- (9CI)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C61358B)  Completed 
    • TOX-27 (NIH Number: 94-3350)  (Peer Review Approval 06/24/1992A )
      Toxicity Studies of Riddelliine (CASRN 23246-96-0) Administered by Gavage to F344 Rats and B6C3F1 Mice.
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0, 0.33, 1.0, 3.3, 10.0, 25.0 MG/KG (5/S/S).
  • 13 weeks (Gavage)  (C61358B)  Completed 
    • TOX-27 (NIH Number: 94-3350)
      Toxicity Studies of Riddelliine (CASRN 23246-96-0) Administered by Gavage to F344 Rats and B6C3F1 Mice.
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R:0, 0.1, 0.33, 1.0, 3.3, 10.0 MG/KG; M:0, 0.33, 1.0, 3.3, 10.0, 25.0 MG/KG (10/S/S).

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C61358C)  Completed 
    • TR-508 (NIH Number: 03-4442)  (Peer Review Approval 10/18/2001A )
      Toxicology and Carcinogenesis Studies of Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: MR: 0 OR 1.0 MG/KG; 50/DOSE FR: 0, 0.01, 0.033, 0.1, 0.33, OR 1.0 MG/KG; 62/DOSE MM: 0, 0.1, 0.3, 1.0, OR 3.0 MG/KG; 50/DOSE FM: 0 OR 3.0 MG/KG; 50/DOSE.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (762742)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A52780)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (532340)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive