Testing Status of Carisoprodol 10248-H
CASRN: 78-44-4
Formula: C12-H24-N2-O4
Synonyms/Common Names
- Carbamic acid, (1-methylethyl)-, 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester
Short-Term Toxicity
- 2 weeks (Gavage)
(C56235A)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13 weeks (Gavage)
(C56235A)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 25, OR 400 MG/KG/10 PER GROUP.
- 13 weeks (Gavage)
(C56235B)
Completed
- TOX-56 (NIH Number: 00-4404)
Toxicity Studies of Carisoprodol Administered by Gavage to F344/N Rats and B6C3F1 Mice - Rats: F344/N; Mice: B6C3F1
- Dose: 0, 25, 400 MG/KG/5 PER GROUP.
- TOX-56 (NIH Number: 00-4404)
- 13 weeks (Gavage)
(C56235C)
Completed
- TOX-56 (NIH Number: 00-4404)
(Tox Peer Review 01/29/1999A )
Toxicity Studies of Carisoprodol Administered by Gavage to F344/N Rats and B6C3F1 Mice - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 100, 200, 400, OR 800 MG/KG; 10/SEX/GROUP M: 0, 600, 1200, OR 1600 MG/KG; 10/SEX/GROUP.
- TOX-56 (NIH Number: 00-4404)
(Tox Peer Review 01/29/1999A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(789521)
Completed
- Sister Chromatid Exchange Equivocal
- Chromosome Aberrations Positive
- Micronucleus
(A09820)
Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Negative
- Female Negative
- Mouse Lymphoma
(071860)
Completed
- Mice
- Positive
- Salmonella
(238333)
Completed
- Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
- Negative
Organ Systems Toxicity
- 27 weeks Continuous Breeding (Legacy) (Gavage)
(RACB88037)
Completed
- Male and Female Mice: Swiss
- Dose: 0, 100, 300, 600, 900, 1200 MG/KG/DAY; 0, 300, 750, 1200 MG/KG/DAY; 0, 1200 MG/KG/DAY; 0, 300, 750, 1200 MG/KG/DAY.