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Testing Status of C.I. Direct Blue 218 10249-L

 

CASRN: 28407-37-6

Formula: C32-H16-Cu2-N6-O16-S4.4Na

Synonyms/Common Names

  • Blue 218, C.I. Direct
  • Copper, (mu-((tetrahydrogen 3,3'-((3,3'-dihydroxy-4,4'-biphenylene)bis(azo))bis(5-amino-4-hydroxy-2,7-naphthalenedisulfonato))(4-)))di-, tetrasodium salt

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C60877A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C60877A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 3000, 20000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C60877B)  Completed 
    • TR-430 (NIH Number: 94-3161)  (Peer Review Approval 12/01/1992A )
      Toxicology and Carcinogenesis Studies of C.I. Direct Blue 218 in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 1000, 3000, 10000 PPM/60 PER GROUP.
  • 2-Year (Dosed-Feed)  (C60877B)  Completed 
    • TR-430 (NIH Number: 94-3161)  (Peer Review Approval 12/01/1992A )
      Toxicology and Carcinogenesis Studies of C.I. Direct Blue 218 in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 1000, 3000, 10000 PPM/60 PER GROUP.

Genetic Toxicology

  • Drosophila  (667824)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (376714)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Salmonella Reduction  (693029)  Completed 
    • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
    •  Negative 
  • Salmonella  (671973)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative