Testing Status of C.I. Direct Blue 218 10249-L
CASRN: 28407-37-6
Formula: C32-H16-Cu2-N6-O16-S4.4Na
Synonyms/Common Names
- Blue 218, C.I. Direct
- Copper, (mu-((tetrahydrogen 3,3'-((3,3'-dihydroxy-4,4'-biphenylene)bis(azo))bis(5-amino-4-hydroxy-2,7-naphthalenedisulfonato))(4-)))di-, tetrasodium salt
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C60877A)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C60877A)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 3000, 20000 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C60877B)
Completed
- TR-430 (NIH Number: 94-3161)
(Peer Review Approval 12/01/1992A )
Toxicology and Carcinogenesis Studies of C.I. Direct Blue 218 in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Some Evidence
- Female Rats No Evidence
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: R&M: 0, 1000, 3000, 10000 PPM/60 PER GROUP.
- TR-430 (NIH Number: 94-3161)
(Peer Review Approval 12/01/1992A )
- 2-Year (Dosed-Feed)
(C60877B)
Completed
- TR-430 (NIH Number: 94-3161)
(Peer Review Approval 12/01/1992A )
Toxicology and Carcinogenesis Studies of C.I. Direct Blue 218 in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Some Evidence
- Female Rats No Evidence
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: R&M: 0, 1000, 3000, 10000 PPM/60 PER GROUP.
- TR-430 (NIH Number: 94-3161)
(Peer Review Approval 12/01/1992A )
Genetic Toxicology
- Drosophila
(667824)
Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(376714)
Completed
- Sister Chromatid Exchange Weakly Positive
- Chromosome Aberrations Negative
- Salmonella Reduction
(693029)
Completed
- Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
- Negative
- Salmonella
(671973)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative