Testing Status of Citral 10251-N
CASRN: 5392-40-5
Formula: C10-H16-O
Synonyms/Common Names
- 3,7-Dimethyl-2,6-octadienal
Short-Term Toxicity
- 2 weeks (Gavage)
(C56348B)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 0.625, 1.25, AND 2.5% BY WEIGHT.
- 2 weeks (Microencapsulation in Feed)
(C56348C)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 0.625, 1.25, 2.5, 5.0, AND 10% BY WEIGHT/5 PER GROUP.
- 13 weeks (Microencapsulation in Feed)
(C56348A)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 3900, 7800, 15600, OR 31300 PPM.
Long-Term Carcinogenicity
- 2 years (Microencapsulation in Feed)
(C56348A)
Completed
- TR-505 (NIH Number: 03-4439)
(Peer Review Approval 05/03/2001A )
Toxicology and Carcinogenesis Studies of Citral (Microencapsulated) (CASRN 5392-40-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice Equivocal Evidence
- Dose: R: 0 (UNTREATED), 0 (VEHICLE), 1000, 2000, OR 4000 PPM M: 0 (UNTREATED), 0 (VEHICLE), 500, 1000, OR 2000 PPM.
- TR-505 (NIH Number: 03-4439)
(Peer Review Approval 05/03/2001A )
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage; Intravenous)
(S0087)
Completed
- Citation: Diliberto JJ, Usha G, Birnbaum LS. Disposition of citral in male Fischer rats. Drug Metab Dispos. 1988 Sep-Oct;16(5):721-7.Pubmed Abstract
- Male Rats: F344/N
- Metabolism (Gavage)
(S0002)
Completed
- Citation: Diliberto JJ, Srinivas P, Overstreet D, Usha G, Burka LT, Birnbaum LS. Metabolism of citral, an alpha,beta-unsaturated aldehyde, in male F344 rats. Drug Metab Dispos. 1990 Nov-Dec;18(6):866-75.Pubmed Abstract
- Male Rats: F344/N
- Dose: 5, 500 MG/KG.
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(881385)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Micronucleus
(A66944)
Completed
- Mice: B6C3F1
- Male Negative
- Micronucleus
(A84250)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(110259)
Completed
- Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
- Negative